The genomics of major psychiatric disorders in a large pedigree from Northern Sweden

Szatkiewicz, Jin (author)

Crowley, James J. (author)

Åberg, Karolina A. (author)

Alaerts, Maaike (author)

Genovese, Giulio (author)

McCarroll, Steven (author)

Del-Favero, Jurgen (author)

(creator_code:org_t)

2019-02-04
2019
English.
In: Translational Psychiatry. - : Nature Publishing Group. - 2158-3188. ; 9

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://www.nature.c...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Abstract Subject headings

We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.

By the author/editor: Szatkiewicz, Jin; Crowley, James J ...; Nordin Adolfsson ...; Åberg, Karolina ...; Alaerts, Maaike; Genovese, Giulio; show more...; McCarroll, Steve ...; Del-Favero, Jurg ...; Adolfsson, Rolf; Sullivan, Patric ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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