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Search: onr:"swepub:oai:DiVA.org:umu-157590" > The genomics of maj...

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  • Szatkiewicz, Jin (author)

The genomics of major psychiatric disorders in a large pedigree from Northern Sweden

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-02-04
  • Nature Publishing Group,2019
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-157590
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-157590URI
  • https://doi.org/10.1038/s41398-019-0414-9DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:140373404URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Crowley, James J. (author)
  • Nordin Adolfsson, AnnelieUmeå universitet,Psykiatri(Swepub:umu)anenon01 (author)
  • Åberg, Karolina A. (author)
  • Alaerts, Maaike (author)
  • Genovese, Giulio (author)
  • McCarroll, Steven (author)
  • Del-Favero, Jurgen (author)
  • Adolfsson, RolfUmeå universitet,Psykiatri(Swepub:umu)road0001 (author)
  • Sullivan, Patrick F.Karolinska Institutet (author)
  • Umeå universitetPsykiatri (creator_code:org_t)

Related titles

  • In:Translational Psychiatry: Nature Publishing Group92158-3188

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