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Alcohol consumption and risk of atrial fibrillation - results from the BiomarCaRE Consortium
- Article/chapterEnglish2018
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Oxford University Press,2018
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LIBRIS-ID:oai:DiVA.org:umu-157627
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-157627URI
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https://doi.org/10.1093/eurheartj/ehy563.P4469DOI
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Language:English
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Summary in:English
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Subject category:vet swepub-contenttype
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Subject category:art swepub-publicationtype
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Supplement: 1Meeting Abstract: P4469
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Background: Atrial fibrillation (AF) is an arrhythmia with high impact on public health. Among modifiable risk factors for the disease the role of alcohol consumption (AC) has remained inconsistent.Purpose: To assess the association between AC and incident AF across European cohorts.Methods: To study the association between self-reported AC and incident AF in N=107,845 community-based individuals from the BiomarCaRE consortium, 106,915 individuals free of AF at baseline were followed up for AF and stroke after AF. We assessed AC using validated questionnaires. Biomarkers N-terminal pro B-type natriuretic peptide (Nt-proBNP) and high sensitivity troponin I (hsTnI) were measured.Results: The median age of individuals was 47.8 years, 48.3% were men. The median of right-winsorized AC was 3 g/day. N=6,055 individuals developed AF (median follow-up time: 13.9 years). In a linear multivariable-adjusted Cox regression analyses, AC was linearly and positively associated with incident AF (Figure), hazard ratio (HR) per g/day 1.009, 95% confidence interval (CI) 1.007- 1.012, P<0.001. For one drink (12g) per day the HR was 1.15, CI 1.12–1.18, P<0.001. There was a high heterogeneity in associations across cohorts.No significant interactions of the association by Nt-proBNP and hsTnI were observed. AC was positively related to stroke risk after diagnosis of AF (HR 1.18, 95% CI 1.04–1.34, P=0.012).Conclusions: In contrast to other cardiovascular diseases, we did not observe a U-shaped association of alcohol with incident AF in the community, but a rather linearly increasing relation.
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Spruenker, N. A.
(author)
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Di Castelnuovo, A.
(author)
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Niiranen, T.
(author)
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Söderberg, StefanUmeå University Hospital(Swepub:umu)stso0001
(author)
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Magnussen, C.
(author)
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Lochen, M. J.
(author)
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Kee, F.
(author)
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Blankenberg, S.
(author)
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Jørgensen, T.
(author)
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Kuulasmaa, K.
(author)
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Zeller, T.
(author)
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Salomaa, V.
(author)
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Iacoviello, L.
(author)
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Schnabel, R.
(author)
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Umeå University Hospital
(creator_code:org_t)
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In:European Heart Journal: Oxford University Press39, s. 902-9030195-668X1522-9645
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Csengeri, D.
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Spruenker, N. A.
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Di Castelnuovo, ...
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Niiranen, T.
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Söderberg, Stefa ...
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Magnussen, C.
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Lochen, M. J.
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Kee, F.
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Blankenberg, S.
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Jørgensen, T.
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Kuulasmaa, K.
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Zeller, T.
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Salomaa, V.
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Iacoviello, L.
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Schnabel, R.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Cardiac and Card ...
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European Heart J ...
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Umeå University