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Prostate cancer ind...
Prostate cancer induces C/EBPβ expression in surrounding epithelial cells which relates to tumor aggressiveness and patient outcome
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- Adamo, Hanibal Hani, 1984- (author)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Pathol, 6M, Umea, Sweden
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- Hammarsten, Peter (author)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Pathol, 6M, Umea, Sweden
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- Hägglöf, Christina (author)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Pathol, 6M, Umea, Sweden
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- Scherdin, Tove Dahl (author)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Pathol, 6M, Umea, Sweden
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- Egevad, Lars (author)
- Karolinska Institutet
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- Stattin, Pär (author)
- Uppsala universitet,Urologkirurgi
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- Halin Bergström, Sofia (author)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Pathol, 6M, Umea, Sweden
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- Bergh, Anders (author)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Pathol, 6M, Umea, Sweden
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(creator_code:org_t)
- 2018-12-11
- 2019
- English.
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In: The Prostate. - : John Wiley & Sons. - 0270-4137 .- 1097-0045. ; 79:5, s. 435-445
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Abstract
Subject headings
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- Background: Implantation of rat prostate cancer cells into the normal rat prostate results in tumor-stimulating adaptations in the tumor-bearing organ. Similar changes are seen in prostate cancer patients and they are related to outcome. One gene previously found to be upregulated in the non-malignant part of tumor-bearing prostate lobe in rats was the transcription factor CCAAT/enhancer-binding protein- (C/EBP).Methods: To explore this further, we examined C/EBP expression by quantitative RT-PCR, immunohistochemistry, and Western blot in normal rat prostate tissue surrounding slow-growing non-metastatic Dunning G, rapidly growing poorly metastatic (AT-1), and rapidly growing highly metastatic (MatLyLu) rat prostate tumors?and also by immunohistochemistry in a tissue microarray (TMA) from prostate cancer patients managed by watchful waiting.Results: In rats, C/EBP mRNA expression was upregulated in the surrounding tumor-bearing prostate lobe. In tumors and in the surrounding non-malignant prostate tissue, C/EBP was detected by immunohistochemistry in some epithelial cells and in infiltrating macrophages. The magnitude of glandular epithelial C/EBP expression in the tumor-bearing prostates was associated with tumor size, distance to the tumor, and metastatic capacity. In prostate cancer patients, high expression of C/EBP in glandular epithelial cells in the surrounding tumor-bearing tissue was associated with accumulation of M1 macrophages (iNOS+) and favorable outcome. High expression of C/EBP in tumor epithelial cells was associated with high Gleason score, high tumor cell proliferation, metastases, and poor outcome.Conclusions: This study suggest that the expression of C/EBP-beta, a transcription factor mediating multiple biological effects, is differentially expressed both in the benign parts of the tumor-bearing prostate and in prostate tumors, and that alterations in this may be related to patient outcome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- biomarkers
- C
- EBP
- prostate cancer
- tumors instruct adjacent tissues
Publication and Content Type
- ref (subject category)
- art (subject category)
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