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Epidemiology of hea...
Epidemiology of heart failure and trends in diagnostic work-up : a retrospective, population-based cohort study in Sweden
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- Lindmark, Krister (author)
- Umeå universitet,Avdelningen för medicin,Heart Centre, Umeå University Hospital, Umeå, Sweden,Umea Univ Hosp, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden;Umea Univ Hosp, Heart Ctr, S-90187 Umea, Sweden
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- Boman, Kurt (author)
- Umeå universitet,Avdelningen för medicin,Research Unit, MedicineGeriatric, Skellefteå County Hospital, Sweden,Umea Univ, Res Unit, Med Geriatr, Skelleftea Cty Hosp,Dept Publ Hlth & Clin Med, Umea, Sweden
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- Olofsson, Mona, 1952- (author)
- Umeå universitet,Avdelningen för medicin,Research Unit, MedicineGeriatric, Skellefteå County Hospital, Sweden,Umea Univ, Res Unit, Med Geriatr, Skelleftea Cty Hosp,Dept Publ Hlth & Clin Med, Umea, Sweden
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- Törnblom, Michael (author)
- IQVIA, Real World & Analyt Solut, Solna, Sweden
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- Levine, Aaron (author)
- IQVIA, Real World & Analyt Solut, Solna, Sweden
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- Castelo-Branco, Anna (author)
- IQVIA, Real World & Analyt Solut, Solna, Sweden
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- Schlienger, Raymond (author)
- Novartis Pharma AG, Quantitat Safety & Epidemiol, Basel, Switzerland
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- Wirta, Sara Bruce (author)
- Novartis Sweden AB, Global RWE Cardiometabol, Stockholm, Sweden
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- Stålhammar, Jan (author)
- Uppsala universitet,Allmänmedicin och preventivmedicin
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- Wikström, Gerhard (author)
- Uppsala universitet,Kardiologi
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(creator_code:org_t)
- Dove medical press, 2019
- 2019
- English.
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In: Clinical Epidemiology. - : Dove medical press. - 1179-1349. ; 11, s. 231-244
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Abstract
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- Purpose: The purpose of this study was to examine the trends in heart failure (HF) epidemiology and diagnostic work-up in Sweden.Methods: Adults with incident HF (>= 2 ICD-10 diagnostic codes) were identified from linked national health registers (cohort 1, 2005-2013) and electronic medical records (cohort 2, 2010-2015; primary/secondary care patients from Uppsala and Vasterbotten). Trends in annual HF incidence rate and prevalence, risk of all-cause and cardiovascular disease (CVD)-related 1-year mortality and use of diagnostic tests 6 months before and after first HF diagnosis (cohort 2) were assessed.Results: Baseline demographic and clinical characteristics were similar for cohort 1 (N=174,537) and 2 (N=8,702), with mean ages of 77.4 and 76.6 years, respectively; almost 30% of patients were aged >= 85 years. From 2010 to 2014, age-adjusted annual incidence rate of HF/1,000 inhabitants decreased (from 3.20 to 2.91, cohort 1; from 4.34 to 3.33, cohort 2), while age-adjusted prevalence increased (from 1.61% to 1.72% and from 2.15% to 2.18%, respectively). Age-adjusted 1-year all-cause and CVD-related mortality was higher in men than in women among patients in cohort 1 (all-cause mortality hazard ratio [HR] men vs women 1.07 [95% CI 1.06-1.09] and CVD-related mortality subdistribution HR for men vs women 1.04 [95% CI 1.02-1.07], respectively). While 83.5% of patients underwent N-terminal pro-B-type natriuretic peptide testing, only 36.4% of patients had an echocardiogram at the time of diagnosis, although this increased overtime. In the national prevalent HF population (patients with a diagnosis in 1997-2004 who survived into the analysis period; N=273,999), death from ischemic heart disease and myocardial infarction declined between 2005 and 2013, while death from HF and atrial fibrillation/flutter increased (P<0.0001 for trends over time).Conclusion: The annual incidence rate of HF declined over time, while prevalence of HF has increased, suggesting that patients with HF were surviving longer over time. Our study confirms that previously reported epidemiological trends persist and remain to ensure proper diagnostic evaluation and management of patients with HF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- diagnosis
- heart failure
- incidence rate
- mortality
- prevalence
- real-world
Publication and Content Type
- ref (subject category)
- art (subject category)
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Lindmark, Kriste ...
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Boman, Kurt
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Olofsson, Mona, ...
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Törnblom, Michae ...
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Levine, Aaron
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Castelo-Branco, ...
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Schlienger, Raym ...
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Wirta, Sara Bruc ...
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Stålhammar, Jan
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Clinical Epidemi ...
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Umeå University
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Uppsala University