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Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma
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Brinkman, Paul (author)
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Wagener, Ariane H. (author)
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Hekking, Pieter-Paul (author)
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Bansal, Aruna T. (author)
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Maitland-van der Zee, Anke-Hilse (author)
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Wang, Yuanyue (author)
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Weda, Hans (author)
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Knobel, Hugo H. (author)
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Vink, Teunis J. (author)
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Rattray, Nicholas J. (author)
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D'Amico, Arnaldo (author)
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Pennazza, Giorgio (author)
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Santonico, Marco (author)
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Lefaudeux, Diane (author)
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De Meulder, Bertrand (author)
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Auffray, Charles (author)
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Bakke, Per S. (author)
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Caruso, Massimo (author)
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Chanez, Pascal (author)
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Chung, Kian F. (author)
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Corfield, Julie (author)
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- Dahlen, Sven-Erik (author)
- Karolinska Institutet
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Djukanovic, Ratko (author)
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Geiser, Thomas (author)
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Horvath, Ildiko (author)
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Krug, Nobert (author)
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Musial, Jacek (author)
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Sun, Kai (author)
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Riley, John H. (author)
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Shaw, Dominic E. (author)
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- Sandström, Thomas, 1957- (author)
- Umeå universitet,Avdelningen för medicin
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Sousa, Ana R. (author)
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Montuschi, Paolo (author)
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Fowler, Stephen J. (author)
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Sterk, Peter J. (author)
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- English.
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In: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 143:5, s. 1811-1820.e7
- Related links:
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http://www.jacionlin...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Severe asthma is a heterogeneous condition, as shown by independent cluster analyses based on demographic, clinical, and inflammatory characteristics. A next step is to identify molecularly driven phenotypes using “omics” technologies. Molecular fingerprints of exhaled breath are associated with inflammation and can qualify as noninvasive assessment of severe asthma phenotypes.Objectives: We aimed (1) to identify severe asthma phenotypes using exhaled metabolomic fingerprints obtained from a composite of electronic noses (eNoses) and (2) to assess the stability of eNose-derived phenotypes in relation to withinpatient clinical and inflammatory changes.Methods: In this longitudinal multicenter study exhaled breath samples were taken from an unselected subset of adults with severe asthma from the U-BIOPRED cohort. Exhaled metabolites were analyzed centrally by using an assembly of eNoses. Unsupervised Ward clustering enhanced by similarity profile analysis together with K-means clustering was performed. For internal validation, partitioning around medoids and topological data analysis were applied. Samples at 12 to 18 months of prospective follow-up were used to assess longitudinal within-patient stability.Results: Data were available for 78 subjects (age, 55 years [interquartile range, 45-64 years]; 41% male). Three eNosedriven clusters (n = 26/33/19) were revealed, showing differences in circulating eosinophil (P = .045) and neutrophil (P = .017) percentages and ratios of patients using oral corticosteroids (P = .035). Longitudinal within-patient cluster stability was associated with changes in sputum eosinophil percentages (P = .045).Conclusions: We have identified and followed up exhaled molecular phenotypes of severe asthma, which were associated with changing inflammatory profile and oral steroid use. This suggests that breath analysis can contribute to the management of severe asthma.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Electronic nose technology
- exhaled breath
- volatile organic compound
- follow-up
- severe asthma
- unbiased clustering
- eosinophils
- neutrophils
- oral corticosteroids
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Brinkman, Paul
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Wagener, Ariane ...
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Hekking, Pieter- ...
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Bansal, Aruna T.
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Maitland-van der ...
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Wang, Yuanyue
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show more...
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Weda, Hans
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Knobel, Hugo H.
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Vink, Teunis J.
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Rattray, Nichola ...
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D'Amico, Arnaldo
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Pennazza, Giorgi ...
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Santonico, Marco
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Lefaudeux, Diane
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De Meulder, Bert ...
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Auffray, Charles
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Bakke, Per S.
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Caruso, Massimo
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Chanez, Pascal
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Chung, Kian F.
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Corfield, Julie
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Dahlen, Sven-Eri ...
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Djukanovic, Ratk ...
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Geiser, Thomas
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Horvath, Ildiko
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Krug, Nobert
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Musial, Jacek
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Sun, Kai
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Riley, John H.
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Shaw, Dominic E.
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Sandström, Thoma ...
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Sousa, Ana R.
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Montuschi, Paolo
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Fowler, Stephen ...
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Sterk, Peter J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Journal of Aller ...
- By the university
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Umeå University
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Karolinska Institutet