Search: onr:"swepub:oai:DiVA.org:umu-159535" >
The prognostic valu...
The prognostic value of pre-treatment thrombocytosis in two cohorts of patients with non-small cell lung cancer treated with curatively intended chemoradiotherapy
-
- Holgersson, Georg (author)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Uppsala Univ Hosp, Dept Immunol Genet & Pathol
-
- Bergström, Stefan (author)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Uppsala Univ Hosp, Dept Immunol Genet & Pathol
-
- Hallqvist, Anders (author)
- Institutionen för Onkologi, Sahlgrenska Universitetssjukhuset,Sahlgrens Univ Hosp, Dept Oncol
-
show more...
-
- Liv, Per, 1979- (author)
- Uppsala universitet,Umeå universitet,Institutionen för epidemiologi och global hälsa,Institutionen för samhällsmedicin och rehabilitering,Avdelningen för medicin,Centrum för forskning och utveckling Region Gävleborg,Centrum för klinisk forskning, Gävleborg
-
- Nilsson, R. Jonas A. (author)
- Uppsala universitet,Umeå universitet,Onkologi,Centrum för forskning och utveckling, Uppsala Universitet / Region Gävleborg, Gävle sjukhus, Gävle, Sverige,Centrum för klinisk forskning, Gävleborg,Umeå Univ Hosp, Dept Radiat Sci & Oncol
-
- Willén, Linda, 1979- (author)
- Uppsala universitet,Umeå universitet,Onkologi,Centrum för forskning och utveckling, Uppsala Universitet / Region Gävleborg, Gävle sjukhus, Gävle, Sverige,Centrum för klinisk forskning, Gävleborg,Umeå Univ Hosp, Dept Radiat Sci & Oncol
-
- Nyman, Jan (author)
- Institutionen för Onkologi, Sahlgrenska Universitetssjukhuset,Sahlgrens Univ Hosp, Dept Oncol
-
- Ekman, Simon (author)
- Karolinska Institutet
-
- Henriksson, Roger (author)
- Umeå universitet,Onkologi,Umeå Univ Hosp, Dept Radiat Sci & Oncol
-
- Bergqvist, Michael (author)
- Uppsala universitet,Umeå universitet,Onkologi,Centrum för forskning och utveckling Region Gävleborg,Centrum för klinisk forskning, Gävleborg,Umeå Univ Hosp, Dept Radiat Sci & Oncol
-
show less...
-
(creator_code:org_t)
- Bratislava : AEPress, 2017
- 2017
- English.
-
In: Neoplasma (Bratislava). - Bratislava : AEPress. - 0028-2685 .- 1338-4317. ; 64:6, s. 909-915
- Related links:
-
http://www.elis.sk/d...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.4...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Chemoradiotherapy is the standard of care for inoperable stage III non-small cell lung cancer (NSCLC). This treatment, however, offers only a small chance of cure and is associated with many side effects. Little research has been made concerning which patients benefit most/least from the treatment. The present study evaluates the prognostic value of anemia, leukocytosis and thrombocytosis at diagnosis in this treatment setting. In the present study, data were collected retrospectively for 222 patients from two different phase II studies conducted between 2002-2007 in Sweden with patients treated with chemoradiotherapy for stage IIIA-IIIB NSCLC. Clinical data and the serum values of hemoglobin (Hgb), White blood cells (WBC) and Platelets (Plt) at enrollment were collected for all patients and studied in relation to overall survival using Kaplan-Meier product-limit estimates and a multivariate Cox proportional hazards regression model. The results showed that patients with thrombocytosis (Plt > 350 x 109 /L) had a shorter median overall survival (14.5 months) than patients with normal Plt at baseline (23.7 months). Patients with leukocytosis (WBC > 9 x 109 /L) had a shorter median survival (14.9 months) than patients with a normal WBC at baseline (22.5 months). However, in a multivariate model including all lab parameters and clinical factors, only thrombocytosis and performance status displayed a prognostic significance. In Conclusion, thrombocytosis showed to be an independent prognostic marker associated with shorter overall survival in stage III NSCLC treated with curatively intended chemoradiotherapy. This knowledge can potentially be used together with established prognostic factors, such as performance status when choosing the optimal therapy for the individual patient in this clinical setting
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- NSCLC
- anemia
- leukocytosis
- thrombocytosis
- prognostic
- survival
- Oncology
- onkologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Holgersson, Geor ...
-
Bergström, Stefa ...
-
Hallqvist, Ander ...
-
Liv, Per, 1979-
-
Nilsson, R. Jona ...
-
Willén, Linda, 1 ...
-
show more...
-
Nyman, Jan
-
Ekman, Simon
-
Henriksson, Roge ...
-
Bergqvist, Micha ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Neoplasma (Brati ...
- By the university
-
Umeå University
-
Uppsala University
-
Karolinska Institutet