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Heterogeneity of Co...
Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries : A Multinational Cohort Study
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- Murphy, Neil (author)
- International Agency for Research on Cancer, World Health Organization
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Ward, Heather A. (author)
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Jenab, Mazda (author)
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Rothwell, Joseph A. (author)
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Boutron-Ruault, Marie-Christine (author)
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Carbonnel, Franck (author)
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Kvaskoff, Marina (author)
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Kaaks, Rudolf (author)
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Kühn, Tilman (author)
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Boeing, Heiner (author)
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Aleksandrova, Krasimira (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Skeie, Guri (author)
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Borch, Kristin Benjaminsen (author)
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Tjønneland, Anne (author)
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Kyrø, Cecilie (author)
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Overvad, Kim (author)
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Dahm, Christina C. (author)
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Jakszyn, Paula (author)
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Sánchez, Maria-Jose (author)
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Gil, Leire (author)
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Huerta, José M. (author)
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Barricarte, Aurelio (author)
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Ramón Quirós, J. (author)
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Bradbury, Kathryn E. (author)
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Trichopoulou, Antonia (author)
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La Vecchia, Carlo (author)
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Karakatsani, Anna (author)
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Palli, Domenico (author)
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Grioni, Sara (author)
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Tumino, Rosario (author)
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Fasanelli, Francesca (author)
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Panico, Salvatore (author)
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Bueno-de-Mesquita, Bas (author)
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Peeters, Petra H. (author)
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Gylling, Björn (author)
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- Myte, Robin (author)
- Umeå universitet,Onkologi
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- Jirström, Karin (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Terapeutisk patologi,Institutionen för kliniska vetenskaper, Lund,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Personalized Pathology & Cancer Therapy,Lund University Research Groups,Therapeutic pathology,Department of Clinical Sciences, Lund
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- Berntsson, Jonna (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Personalized Pathology & Cancer Therapy,Lund University Research Groups
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Xue, Xiaonan (author)
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Riboli, Elio (author)
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Cross, Amanda J. (author)
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Gunter, Marc J. (author)
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(creator_code:org_t)
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et al
- Elsevier, 2019
- 2019
- English.
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In: Clinical Gastroenterology and Hepatology. - : Elsevier. - 1542-3565 .- 1542-7714. ; 17:7, s. 1323-1331
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Abstract
Subject headings
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- Background & Aims: Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that have examined this hypothesis have yielded inconsistent results, possibly because most studies have been of insufficient size to identify heterogeneous associations with precision.Methods: In the European Prospective Investigation into Cancer and Nutrition study, we used multivariable joint Cox proportional hazards models, which accounted for tumorsat different anatomical sites (proximal colon, distal colon, and rectum) as competing risks, to examine the relationships between 14 established/suspected lifestyle, anthropometric, and reproductive/menstrual risk factors with colorectal cancer risk. Heterogeneity across sites was tested using Wald tests.Results: After a median of 14.9 years of follow-up of 521,330 men and women, 6291 colorectal cancer cases occurred. Physical activity was related inversely to proximal colon and distal colon cancer, but not to rectal cancer (P heterogeneity = .03). Height was associated positively with proximal and distal colon cancer only, but not rectal cancer (P heterogeneity = .0001). For men, but not women, heterogeneous relationships were observed for body mass index (P heterogeneity = .008) and waist circumference (P heterogeneity = .03), with weaker positive associations found for rectal cancer, compared with proximal and distal colon cancer. Current smoking was associated with a greater risk of rectal and proximal colon cancer, but not distal colon cancer (P heterogeneity = .05). No heterogeneity by anatomical site was found for alcohol consumption, diabetes, nonsteroidal anti-inflammatory drug use, and reproductive/menstrual factors.Conclusions: The relationships between physical activity, anthropometry, and smoking with colorectal cancer risk differed by subsite, supporting the hypothesis that tumors in different anatomical regions may have distinct etiologies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Colorectal Cancer
- Risk Factors
- Anatomic Subsite
- Heterogeneity
- Proximal Colon
- Distal Colon
- Rectum
- Anatomic Subsite
- Colorectal Cancer
- Distal Colon
- Heterogeneity
- Proximal Colon
- Rectum
- Risk Factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Murphy, Neil
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Ward, Heather A.
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Jenab, Mazda
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Rothwell, Joseph ...
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Boutron-Ruault, ...
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Carbonnel, Franc ...
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show more...
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Kvaskoff, Marina
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Kaaks, Rudolf
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Kühn, Tilman
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Boeing, Heiner
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Aleksandrova, Kr ...
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Weiderpass, Elis ...
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Skeie, Guri
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Borch, Kristin B ...
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Tjønneland, Anne
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Kyrø, Cecilie
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Overvad, Kim
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Dahm, Christina ...
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Jakszyn, Paula
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Sánchez, Maria-J ...
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Gil, Leire
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Huerta, José M.
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Barricarte, Aure ...
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Ramón Quirós, J.
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Khaw, Kay-Tee
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Wareham, Nick
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Bradbury, Kathry ...
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Trichopoulou, An ...
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La Vecchia, Carl ...
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Karakatsani, Ann ...
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Palli, Domenico
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Grioni, Sara
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Tumino, Rosario
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Fasanelli, Franc ...
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Gylling, Björn
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Myte, Robin
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Jirström, Karin
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Berntsson, Jonna
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Xue, Xiaonan
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Riboli, Elio
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Cross, Amanda J.
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Gunter, Marc J.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Clinical Gastroe ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet