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Heterogeneity of Co...
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Murphy, NeilInternational Agency for Research on Cancer, World Health Organization
(author)
Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries : A Multinational Cohort Study
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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Elsevier,2019
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-159850
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-159850URI
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https://doi.org/10.1016/j.cgh.2018.07.030DOI
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https://lup.lub.lu.se/record/da4ab6ce-7e41-496d-8f81-cfebcb90392bURI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140965095URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background & Aims: Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that have examined this hypothesis have yielded inconsistent results, possibly because most studies have been of insufficient size to identify heterogeneous associations with precision.Methods: In the European Prospective Investigation into Cancer and Nutrition study, we used multivariable joint Cox proportional hazards models, which accounted for tumorsat different anatomical sites (proximal colon, distal colon, and rectum) as competing risks, to examine the relationships between 14 established/suspected lifestyle, anthropometric, and reproductive/menstrual risk factors with colorectal cancer risk. Heterogeneity across sites was tested using Wald tests.Results: After a median of 14.9 years of follow-up of 521,330 men and women, 6291 colorectal cancer cases occurred. Physical activity was related inversely to proximal colon and distal colon cancer, but not to rectal cancer (P heterogeneity = .03). Height was associated positively with proximal and distal colon cancer only, but not rectal cancer (P heterogeneity = .0001). For men, but not women, heterogeneous relationships were observed for body mass index (P heterogeneity = .008) and waist circumference (P heterogeneity = .03), with weaker positive associations found for rectal cancer, compared with proximal and distal colon cancer. Current smoking was associated with a greater risk of rectal and proximal colon cancer, but not distal colon cancer (P heterogeneity = .05). No heterogeneity by anatomical site was found for alcohol consumption, diabetes, nonsteroidal anti-inflammatory drug use, and reproductive/menstrual factors.Conclusions: The relationships between physical activity, anthropometry, and smoking with colorectal cancer risk differed by subsite, supporting the hypothesis that tumors in different anatomical regions may have distinct etiologies.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Ward, Heather A.
(author)
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Jenab, Mazda
(author)
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Rothwell, Joseph A.
(author)
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Boutron-Ruault, Marie-Christine
(author)
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Carbonnel, Franck
(author)
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Kvaskoff, Marina
(author)
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Kaaks, Rudolf
(author)
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Kühn, Tilman
(author)
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Boeing, Heiner
(author)
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Aleksandrova, Krasimira
(author)
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Weiderpass, ElisabeteKarolinska Institutet
(author)
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Skeie, Guri
(author)
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Borch, Kristin Benjaminsen
(author)
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Tjønneland, Anne
(author)
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Kyrø, Cecilie
(author)
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Overvad, Kim
(author)
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Dahm, Christina C.
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Jakszyn, Paula
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Sánchez, Maria-Jose
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Gil, Leire
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Huerta, José M.
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Barricarte, Aurelio
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Ramón Quirós, J.
(author)
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Khaw, Kay-Tee
(author)
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Wareham, Nick
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Bradbury, Kathryn E.
(author)
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Trichopoulou, Antonia
(author)
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La Vecchia, Carlo
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Karakatsani, Anna
(author)
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Palli, Domenico
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Grioni, Sara
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Tumino, Rosario
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Fasanelli, Francesca
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Panico, Salvatore
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Bueno-de-Mesquita, Bas
(author)
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Peeters, Petra H.
(author)
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Gylling, Björn
(author)
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Myte, RobinUmeå universitet,Onkologi(Swepub:umu)romy0001
(author)
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Jirström, KarinLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Terapeutisk patologi,Institutionen för kliniska vetenskaper, Lund,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Personalized Pathology & Cancer Therapy,Lund University Research Groups,Therapeutic pathology,Department of Clinical Sciences, Lund(Swepub:lu)pat-kji
(author)
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Berntsson, JonnaLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Personalized Pathology & Cancer Therapy,Lund University Research Groups(Swepub:lu)jo6056be
(author)
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Xue, Xiaonan
(author)
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Riboli, Elio
(author)
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Cross, Amanda J.
(author)
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Gunter, Marc J.
(author)
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Karolinska InstitutetInternational Agency for Research on Cancer, World Health Organization
(creator_code:org_t)
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et al.
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In:Clinical Gastroenterology and Hepatology: Elsevier17:7, s. 1323-13311542-35651542-7714
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Murphy, Neil
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Ward, Heather A.
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Jenab, Mazda
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Rothwell, Joseph ...
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Boutron-Ruault, ...
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Carbonnel, Franc ...
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Kvaskoff, Marina
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Kaaks, Rudolf
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Kühn, Tilman
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Boeing, Heiner
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Aleksandrova, Kr ...
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Weiderpass, Elis ...
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Skeie, Guri
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Borch, Kristin B ...
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Tjønneland, Anne
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Kyrø, Cecilie
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Overvad, Kim
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Dahm, Christina ...
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Jakszyn, Paula
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Sánchez, Maria-J ...
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Gil, Leire
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Huerta, José M.
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Barricarte, Aure ...
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Ramón Quirós, J.
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Khaw, Kay-Tee
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Wareham, Nick
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Bradbury, Kathry ...
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Trichopoulou, An ...
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La Vecchia, Carl ...
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Karakatsani, Ann ...
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Palli, Domenico
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Grioni, Sara
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Tumino, Rosario
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Fasanelli, Franc ...
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Gylling, Björn
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Myte, Robin
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Jirström, Karin
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Berntsson, Jonna
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Xue, Xiaonan
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Riboli, Elio
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Cross, Amanda J.
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Gunter, Marc J.
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Umeå University
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Lund University
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Karolinska Institutet