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Time course of deco...
Time course of decompensation after angiotensin II and high-salt diet in Balb/CJ mice suggests pulmonary hypertension-induced cardiorenal syndrome
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- Becirovic-Agic, Mediha (author)
- Uppsala universitet,Integrativ Fysiologi
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- Jönsson, Sofia (author)
- Uppsala universitet,Integrativ Fysiologi
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Tveitarås, Maria K. (author)
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Skogstrand, Trude (author)
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Karlsen, Tine, V (author)
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Lidén, Åsa (author)
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Leh, Sabine (author)
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- Ericsson, Madelene (author)
- Umeå universitet,Fysiologisk kemi
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- Nilsson, Stefan K., 1979- (author)
- Umeå universitet,Fysiologisk kemi
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Reed, Rolf K. (author)
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- Hultström, Michael, 1978- (author)
- Uppsala universitet,Anestesiologi och intensivvård,Integrativ Fysiologi,Department of Biomedicine, University of Bergen, Bergen, Norway
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(creator_code:org_t)
- the American Physiological Society, 2019
- 2019
- English.
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In: American Journal of Physiology. Regulatory Integrative and Comparative Physiology. - : the American Physiological Society. - 0363-6119 .- 1522-1490. ; 316:5, s. R563-R570
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https://doi.org/10.1...
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Abstract
Subject headings
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- The genetic background of a mouse strain determines its susceptibility to disease. C57BL/6J and Balb/CJ are two widely used inbred mouse strains that we found react dramatically differently to angiotensin II and high-salt diet (ANG II + Salt). Balb/CJ show increased mortality associated with anuria and edema formation while C57BL/6J develop arterial hypertension but do not decompensate and die. Clinical symptoms of heart failure in Balb/CJ mice gave the hypothesis that ANG II + Salt impairs cardiac function and induces cardiac remodeling in male Balb/CJ but not in male C57BL/6J mice. To test this hypothesis, we measured cardiac function using echocardiography before treatment and every day for 7 days during treatment with ANG II + Salt. Interestingly, pulsed wave Doppler of pulmonary artery flow indicated increased pulmonary vascular resistance and right ventricle systolic pressure in Balb/CJ mice, already 24 h after ANG II + Salt treatment was started. In addition, Balb/CJ mice showed abnormal diastolic filling indicated by reduced early and late filling and increased isovolumic relaxation time. Furthermore, Balb/CJ exhibited lower cardiac output compared with C57BL/6J even though they retained more sodium and water, as assessed using metabolic cages. Left posterior wall thickness increased during ANG II + Salt treatment but did not differ between the strains. In conclusion, ANG II + Salt treatment causes early restriction of pulmonary flow and reduced left ventricular filling and cardiac output in Balb/CJ, which results in fluid retention and peripheral edema. This makes Balb/CJ a potential model to study the adaptive capacity of the heart for identifying new disease mechanisms and drug targets.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- animal model
- congestive heart failure
- pulmonary hypertension
- right-sided heart failure
Publication and Content Type
- ref (subject category)
- art (subject category)
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Becirovic-Agic, ...
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Jönsson, Sofia
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Tveitarås, Maria ...
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Skogstrand, Trud ...
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Karlsen, Tine, V
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Lidén, Åsa
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Leh, Sabine
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Ericsson, Madele ...
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Nilsson, Stefan ...
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Reed, Rolf K.
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Hultström, Micha ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
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MEDICAL AND HEAL ...
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Umeå University
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Uppsala University