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Pro-atherogenic pro...
Pro-atherogenic properties of lipopolysaccharide from the periodontal pathogen Actinobacillus actinomycetemcomitans.
- Article/chapterEnglish2006
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LIBRIS-ID:oai:DiVA.org:umu-16016
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-16016URI
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https://doi.org/10.1179/096805106X89099DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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An association between cardiovascular and periodontal disease may be due to lipopolysaccharide (LPS)-promoted release of inflammatory mediators, adverse alterations of the lipoprotein profile, and an imbalance in cholesterol homeostasis. Since periodontopathogenic potential differs between serotypes of a major periodontal pathogen, Actinobacillus actinomycetemcomitans, we studied the pro-atherogenic properties of LPS preparations from serotypes b and d strains on macrophages (RAW 264.7). A. actinomycetemcomitans LPS preparations induced a time-dependent release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). LPS induced foam cell formation and cholesteryl ester accumulation from native low density lipoprotein in the following order: A. actinomycetemcomitans strains JP2 (serotype b) > Y4 (serotype b) > IDH781 (serotype d). mRNA expression levels of scavenger receptor class B, type-I, and ATP-binding cassette transporter-1, receptors mediating cholesterol efflux from macrophages, were decreased by LPS preparations. The results suggest that the pro-atherogenic potential of A. actinomycetemcomitans LPS may depend on the infecting strain and correlate with the periodontopathogenic potential of the pathogen.
Added entries (persons, corporate bodies, meetings, titles ...)
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Lehto, M
(author)
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Tuomainen, AM
(author)
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Jauhiainen, M
(author)
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Malle, E
(author)
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Asikainen, SirkkaUmeå universitet,Oral mikrobiologi(Swepub:umu)sias0001
(author)
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Pussinen, PJ
(author)
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Umeå universitetOral mikrobiologi
(creator_code:org_t)
Related titles
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In:Journal of Endotoxin Research12:1, s. 57-640968-05191743-2839
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