SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:umu-160627"
 

Search: onr:"swepub:oai:DiVA.org:umu-160627" > Association of Plas...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Zheng, Ju-ShengUniversity of Cambridge (author)

Association of Plasma Vitamin D Metabolites With Incident Type 2 Diabetes : EPIC-InterAct Case-Cohort Study

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2018-11-09
  • Oxford University Press,2019
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-160627
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-160627URI
  • https://doi.org/10.1210/jc.2018-01522DOI
  • https://lup.lub.lu.se/record/bc5b6236-35a2-4292-bd48-583ffae4daf6URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Existing evidence for the prospective association of vitamin D status with type 2 diabetes (T2D) is focused almost exclusively on circulating total 25-hydroxyvitamin D [25(OH)D] without distinction between its subtypes: nonepimeric and epimeric 25(OH)D3 stereoisomers, and 25(OH)D2, the minor component of 25(OH)D. We aimed to investigate the prospective associations of circulating levels of the sum and each of these three metabolites with incident T2D.Methods: This analysis in the European Prospective Investigation into Cancer and Nutrition (EPIC)–InterAct case-cohort study for T2D included 9671 incident T2D cases and 13,562 subcohort members. Plasma vitamin D metabolites were quantified by liquid chromatography–mass spectrometry. We used a multivariable Prentice-weighted Cox regression to estimate hazard ratios (HRs) of T2D for each metabolite. Analyses were performed separately within country, and estimates were combined across countries using random-effects meta-analysis.Results: The mean concentrations (SD) of total 25(OH)D, nonepimeric 25(OH)D3, epimeric 25(OH)D3, and 25(OH)D2 were 41.1 (17.2), 40.7 (17.3), 2.13 (1.31), and 8.16 (6.52) nmol/L, respectively. Plasma total 25(OH)D and nonepimeric 25(OH)D3 were inversely associated with incident T2D [multivariable-adjusted HR per 1 SD = 0.81 (95% CI, 0.77, 0.86) for both variables], whereas epimeric 25(OH)D3 was positively associated [per 1 SD HR = 1.16 (1.09, 1.25)]. There was no statistically significant association with T2D for 25(OH)D2 [per 1 SD HR = 0.94 (0.76, 1.18)].Conclusions: Plasma nonepimeric 25(OH)D3 was inversely associated with incident T2D, consistent with it being the major metabolite contributing to total 25(OH)D. The positive association of the epimeric form of 25(OH)D3 with incident T2D provides novel information to assess the biological relevance of vitamin D epimerization and vitamin D subtypes in diabetes etiology.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Imamura, FumiakiUniversity of Cambridge (author)
  • Sharp, Stephen J.University of Cambridge (author)
  • van der Schouw, Yvonne T.Utrecht University,University Medical Center Utrecht (author)
  • Sluijs, IvonneUniversity Medical Center Utrecht,Utrecht University (author)
  • Gundersen, Thomas E.Vitas AS (author)
  • Ardanaz, EvaNavarre Public Health Institute (ISPN),CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)(Swepub:lu)extLU-05 (author)
  • Boeing, HeinerGerman Institute of Human Nutrition (author)
  • Bonet, CatalinaBellvitge Biomedical Research Institute (author)
  • Humberto Gomez, JesusMurcia Regional Health Council (author)
  • Dow, CourtneyUniversity of Paris-Saclay (author)
  • Fagherazzi, GuyUniversity of Paris-Saclay (author)
  • Franks, Paul W.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-plf (author)
  • Jenab, MazdaInternational Agency for Research on Cancer, World Health Organization (author)
  • Kuehn, TilmanGerman Cancer Research Centre (author)
  • Kaaks, RudolfGerman Cancer Research Centre (author)
  • Key, Timothy J.University of Oxford (author)
  • Khaw, Kay-TeeUniversity of Cambridge (author)
  • Lasheras, CristinaUniversity of Oviedo (author)
  • Mokoroa, OlatzCIBER Epidemiology and Public Health (CIBERESP),Biodonostia Health Research Institute (author)
  • Mancini, Francesca RomanaUniversity of Paris-Saclay (author)
  • Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (author)
  • Overvad, KimAarhus University (author)
  • Panico, SalvatoreUniversity of Naples Federico II (author)
  • Palli, DomenicoInstitute for Cancer Research, Prevention and Clinical Network (ISPRO) (author)
  • Rolandsson, OlovUmeå University,Umeå universitet,Allmänmedicin(Swepub:umu)olro0005 (author)
  • Sieri, SabinaIstituto Nazionale dei Tumori,University of Cambridge (author)
  • Salamanca-Fernandez, ElenaHospital Clínico Universitario San Cecilio,Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP),University of Granada (author)
  • Sacerdote, CarlottaUniversity of Turin,Centre for Cancer Epidemiology and Prevention (CPO Piemonte) (author)
  • Spijkerman, Annemieke M. W.National Institute for Public Health and the Environment (RIVM) (author)
  • Stepien, MagdalenaInternational Agency for Research on Cancer, World Health Organization (author)
  • Tjonneland, AnneDanish Cancer Society (author)
  • Tumino, RosarioCivic and M.P Arezzo Hospital (author)
  • Butterworth, Adam S. (author)
  • Riboli, ElioImperial College London (author)
  • Danesh, JohnWellcome Trust Sanger Institute,Addenbrooke's Hospital,University of Cambridge (author)
  • Langenberg, ClaudiaUniversity of Cambridge (author)
  • Forouhi, Nita G.University of Cambridge (author)
  • Wareham, Nicholas J.University of Cambridge (author)
  • University of CambridgeUtrecht University (creator_code:org_t)

Related titles

  • In:Journal of Clinical Endocrinology and Metabolism: Oxford University Press104:4, s. 1293-13030021-972X1945-7197

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view