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Discovery of cyclop...
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Giordanetto, Fabrizio
(author)
Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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Elsevier BV,2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-16155
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-16155URI
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https://doi.org/10.1016/j.bmcl.2007.05.034DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We herein report the optimization of cyclopentane- and cyclohexane-1,3-diamine derivatives as novel and potent MCH-R1 antagonists. Structural modifications of the 2-amino-quinoline and thiophene moieties found in the initial lead compound served to improve its metabolic stability profile and MCH-R1 affinity, and revealed unprecedented SAR when compared to other 2-amino-quinoline-containing MCH-R1 antagonists.
Subject headings and genre
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Melanin-concentrating hormone receptor; MCH
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MCH-R1 antagonists
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Obesity
Added entries (persons, corporate bodies, meetings, titles ...)
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Karlsson, Olle
(author)
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Lindberg, Jan
(author)
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Larsson, Lars-Olof
(author)
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Linusson, AnnaUmeå universitet,Kemiska institutionen(Swepub:umu)analin99
(author)
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Evertsson, Emma
(author)
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Morgan, David GA
(author)
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Inghardt, Tord
(author)
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Umeå universitetKemiska institutionen
(creator_code:org_t)
Related titles
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In:Bioorganic & Medicinal Chemistry Letters: Elsevier BV17:15, s. 4232-410960-894X
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