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  • Almby, Kristina E.Uppsala universitet,Klinisk diabetologi och metabolism (author)

Effects of GLP-1 on counter-regulatory responses during hypoglycemia after GBP surgery

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • Bioscientifica,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-161569
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161569URI
  • https://doi.org/10.1530/EJE-19-0171DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390513URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objectives: The aim of the study was to explore the role of GLP-1 receptor activation on the counter-regulation and symptoms of hypoglycemia in subjects who have undergone gastric bypass surgery (GBP).Design: Experimental hyperinsulinemic–hypoglycemic clamp study.Methods: Twelve post-GBP subjects participated in a randomized cross-over study with two hyperinsulinemic, hypoglycemic clamps (glucose nadir 2.7 mmol/L) performed on separate days with concomitant infusions of the GLP-1 analog exenatide or with saline, respectively. Continuous measurements of metabolites and counter-regulatory hormones as well as assessments of heart rate variability and symptoms of hypoglycemia were performed throughout the clamps.Results: No effect of GLP-1 receptor activation on counter-regulatory hormones (glucagon, catecholamines, cortisol, GH) or glucose infusion rate was seen, but we found indications of a downregulation of the sympathetic relative to the parasympathetic nerve activity, as reflected in heart rate variability. No significant differences in symptom of hypoglycemia were observed.Conclusions/interpretation: Short-term exposure to a GLP-1 receptor agonist does not seem to impact the counter-regulatory hormonal and metabolic responses in post-GBP subjects during hypoglycemic conditions, suggesting that the improvement in symptomatic hypoglycemia post-GBP seen following treatment with GLP-1 receptor agonists may be mediated by mechanism not directly involved in counter-regulation.

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  • Abrahamsson, Niclas,1976-Uppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)nicab972 (author)
  • Lundqvist, Martin H.Uppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)marlu858 (author)
  • Hammar, UlfUppsala universitet,Molekylär epidemiologi(Swepub:uu)ulfha881 (author)
  • Thombare, KetanUppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)ketth923 (author)
  • Panagiotou, AmaliaUppsala Univ Hosp, Dept Internal Med, Uppsala, Sweden (author)
  • Karlsson, Anders,1945-Uppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)anderska (author)
  • Sundbom, MagnusUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)magsundb (author)
  • Wiklund, UrbanUmeå universitet,Radiofysik,Umea Univ, Dept Radiat Sci, Biomed Engn, Umea, Sweden(Swepub:umu)urwi0001 (author)
  • Eriksson, JanUppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)janer909 (author)
  • Uppsala universitetKlinisk diabetologi och metabolism (creator_code:org_t)

Related titles

  • In:European Journal of Endocrinology: Bioscientifica181:2, s. 161-1710804-46431479-683X

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