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  • Mofors, J.Karolinska Institutet,Karolinska Univ Hosp, Sweden (author)

Infections increase the risk of developing Sjögren's syndrome

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-04-17
  • Wiley-Blackwell,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-161599
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161599URI
  • https://doi.org/10.1111/joim.12888DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390586URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141227534URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-158981URI
  • https://lup.lub.lu.se/record/145b39fb-fbee-48f3-bc46-1db03b7e1765URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Research Council; Swedish Rheumatism association; King Gustaf the V:th 80-year foundation; Heart-Lung Foundation; Stockholm County Council; Karolinska Institute
  • Objective: Environmental factors have been suggested in the pathogenesis of rheumatic diseases. We here investigated whether infections increase the risk of developing primary Sjögren's syndrome (pSS).Methods: Patients with pSS in Sweden (n = 945) and matched controls from the general population (n = 9048) were included, and data extracted from the National Patient Register to identify infections occurring before pSS diagnosis during a mean observational time of 16.0 years. Data were analysed using conditional logistic regression models. Sensitivity analyses were performed by varying exposure definition and adjusting for previous health care consumption.Results: A history of infection associated with an increased risk of pSS (OR 1.9, 95% CI 1.6–2.3). Infections were more prominently associated with the development of SSA/SSB autoantibody‐positive pSS (OR 2.7, 95% CI 2.0–3.5). When stratifying the analysis by organ system infected, respiratory infections increased the risk of developing pSS, both in patients with (OR 2.9, 95% CI 1.8–4.7) and without autoantibodies (OR 2.1, 95% CI 1.1–3.8), whilst skin and urogenital infections only significantly associated with the development of autoantibody‐positive pSS (OR 3.2, 95% CI 1.8–5.5 and OR 2.7, 95% CI 1.7–4.2). Furthermore, a dose–response relationship was observed for infections and a risk to develop pSS with Ro/SSA and La/SSB antibodies. Gastrointestinal infections were not significantly associated with a risk of pSS.Conclusions: Infections increase the risk of developing pSS, most prominently SSA/SSB autoantibody‐positive disease, suggesting that microbial triggers of immunity may partake in the pathogenetic process of pSS.

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  • Arkema, E. V.Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Div Clin Epidemiol, Stockholm, Sweden,Karolinska University Hospital (author)
  • Björk, A.Karolinska Institutet,Karolinska Univ Hosp, Sweden (author)
  • Westermark, L.Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Sweden (author)
  • Kvarnström, M.Karolinska Institutet (author)
  • Forsblad-d'Elia, HelenaUmeå University,Umeå universitet,Reumatologi,Umea Univ, Rheumatol, Dept Publ Hlth & Clin Med, Umea, Sweden(Swepub:umu)hefo0034 (author)
  • Magnusson Bucher, S.Örebro University (author)
  • Eriksson, PerLinköping University,Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)perer22 (author)
  • Mandl, ThomasLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-tma (author)
  • Nordmark, GunnelUppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Sweden(Swepub:uu)gunnnord (author)
  • Wahren-Herlenius, M.Karolinska Institutet (author)
  • Karolinska InstitutetKarolinska Univ Hosp, Sweden (creator_code:org_t)

Related titles

  • In:Journal of Internal Medicine: Wiley-Blackwell285:6, s. 670-6800954-68201365-2796

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