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PET/MRI and PET/CT ...
PET/MRI and PET/CT hybrid imaging of rectal cancer - description and initial observations from the RECTOPET (REctal Cancer trial on PET/MRI/CT) study
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- Rutegård, Miriam (författare)
- Umeå universitet,Diagnostisk radiologi
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- Båtsman, Malin (författare)
- Umeå universitet,Patologi
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- Axelsson, Jan, 1966- (författare)
- Umeå universitet,Radiofysik
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- Brynolfsson, Patrik (författare)
- Umeå universitet,Radiofysik
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- Brännström, Fredrik (författare)
- Umeå universitet,Kirurgi
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- Rutegård, Jörgen, 1948- (författare)
- Umeå universitet,Kirurgi
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- Ljuslinder, Ingrid, 1968- (författare)
- Umeå universitet,Onkologi
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- Blomqvist, Lennart (författare)
- Umeå universitet,Diagnostisk radiologi
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- Palmqvist, Richard (författare)
- Umeå universitet,Patologi
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- Rutegård, Martin, 1982- (författare)
- Umeå universitet,Kirurgi
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- Riklund, Katrine (författare)
- Umeå universitet,Diagnostisk radiologi
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(creator_code:org_t)
- 2019-07-23
- 2019
- Engelska.
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Ingår i: Cancer Imaging. - : BMC. - 1740-5025 .- 1470-7330. ; 19
- Relaterad länk:
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https://umu.diva-por... (primary) (Raw object)
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https://cancerimagin...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- PurposeThe role of hybrid imaging using F-18-fluoro-2-deoxy-D-glucose positron-emission tomography (FDG-PET), computed tomography (CT) and magnetic resonance imaging (MRI) to improve preoperative evaluation of rectal cancer is largely unknown. To investigate this, the RECTOPET (REctal Cancer Trial on PET/MRI/CT) study has been launched with the aim to assess staging and restaging of primary rectal cancer. This report presents the study workflow and the initial experiences of the impact of PET/CT on staging and management of the first patients included in the RECTOPET study.MethodsThis prospective cohort study, initiated in September 2016, is actively recruiting patients from Region Vasterbotten in Sweden. This pilot study includes patients recruited and followed up until December 2017. All patients had a biopsy-verified rectal adenocarcinoma and underwent a minimum of one preoperative FDG-PET/CT and FDG-PET/MRI examination. These patients were referred to the colorectal cancer multidisciplinary team meeting at Umea University Hospital. All available data were evaluated when making management recommendations. The clinical course was noted and changes consequent to PET imaging were described; surgical specimens underwent dedicated MRI for anatomical matching between imaging and histopathology.ResultsTwenty-four patients have so far been included in the study. Four patients were deemed unresectable, while 19 patients underwent or were scheduled for surgery; one patient was enrolled in a watch-and-wait programme after restaging. Consequent to taking part in the study, two patients were upstaged to M1 disease: one patient was diagnosed with a solitary hepatic metastasis detected using PET/CT and underwent metastasectomy prior to rectal cancer surgery, while one patient with a small, but metabolically active, lung nodulus experienced no change of management. PET/MRI did not contribute to any recorded change in patient management.ConclusionsThe RECTOPET study investigating the role of PET/CT and PET/MRI for preoperative staging of primary rectal cancer patients will provide novel data that clarify the value of adding hybrid to conventional imaging, and the role of PET/CT versus PET/MRI.Trial registrationNCT03846882.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Rectal neoplasm
- Rectal tumour
- Staging
- Lymph nodes
- Tumour deposits
- PET
- CT
- FDG-PET
- CT
- PET
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Rutegård, Miriam
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Båtsman, Malin
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Axelsson, Jan, 1 ...
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Brynolfsson, Pat ...
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Brännström, Fred ...
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Rutegård, Jörgen ...
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Ljuslinder, Ingr ...
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Blomqvist, Lenna ...
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Palmqvist, Richa ...
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Rutegård, Martin ...
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Riklund, Katrine
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Cancer Imaging
- Av lärosätet
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Umeå universitet
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Karolinska Institutet