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Dietary folate inta...
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Park, Jin YoungInternational Agency for Research on Cancer, World Health Organization
(author)
Dietary folate intake and pancreatic cancer risk : Results from the European prospective investigation into cancer and nutrition
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2018-12-21
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John Wiley & Sons,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-162489
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162489URI
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https://doi.org/10.1002/ijc.31830DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140250798URI
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https://lup.lub.lu.se/record/fb6717c1-d1e1-479f-b45d-2c2f41d7e084URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (>= 353 mu g/day) compared to the lowest (<241 mu g/day) was 0.81 (95% CI: 0.51, 1.31; p(trend) = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for >= 353 mu g/day vs. <241 mu g/day, p(trend) = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (p(interaction) = 0.99). We found no association between dietary folate intake and PC risk in this large European study.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Bueno-de-Mesquita, H. BasImperial College London,University Medical Center Utrecht,National Institute for Public Health and the Environment (RIVM)
(author)
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Ferrari, PietroInternational Agency for Research on Cancer, World Health Organization
(author)
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Weiderpass, ElisabeteKarolinska Institutet,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research
(author)
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de Batlle, JordiCIBER Enfermedades Respiratorias (CIBERES)
(author)
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Tjonneland, AnneDanish Cancer Society
(author)
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Kyro, CecilieDanish Cancer Society
(author)
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Rebours, VincianeParis Diderot University,Beaujon Hospital
(author)
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Boutron-Ruault, Marie-ChristineUniversity of Paris-Saclay,Stabilite genetique et oncogenese
(author)
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Mancini, Francesca RomanaStabilite genetique et oncogenese,University of Paris-Saclay
(author)
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Katzke, VerenaGerman Cancer Research Centre
(author)
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Kuehn, TilmanGerman Cancer Research Centre
(author)
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Boeing, HeinerGerman Institute of Human Nutrition
(author)
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Trichopoulou, AntoniaHellenic Health Foundation, Athens
(author)
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La Vecchia, CarloUniversity of Milan,Hellenic Health Foundation, Athens
(author)
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Kritikou, MariaHellenic Health Foundation, Athens
(author)
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Masala, Giovanna
(author)
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Pala, ValeriaIstituto Nazionale dei Tumori
(author)
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Tumino, Rosario
(author)
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Panico, SalvatoreUniversity of Naples Federico II
(author)
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Peeters, Petra H.Imperial College London,University Medical Center Utrecht
(author)
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Skeie, GuriUiT The Arctic University of Norway, Tromsø
(author)
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Merino, Susana
(author)
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Duell, Eric J.Bellvitge University Hospital-IDIBELL
(author)
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Rodriguez-Barranco, MiguelUniversity of Granada,CIBER Epidemiology and Public Health (CIBERESP)
(author)
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Dorronsoro, MirenCIBER Epidemiology and Public Health (CIBERESP)
(author)
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Chirlaque, Maria-DoloresUniversity of Murcia,Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
(author)
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Ardanaz, EvaHealth Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
(author)
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Gylling, Björn,1978-Umeå University,Umeå universitet,Patologi(Swepub:umu)bjgy0001
(author)
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Schneede, JörnUmeå University,Umeå universitet,Farmakologi(Swepub:umu)josc0012
(author)
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Ericson, UlrikaLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)medf-upe
(author)
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Sternby, HannaLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)med-hse
(author)
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Khaw, Kay-TeeUniversity of Cambridge
(author)
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Bradbury, Kathryn E.University of Oxford
(author)
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Huybrechts, IngeInternational Agency for Research on Cancer, World Health Organization
(author)
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Aune, DagfinnImperial College London,Bjørknes University College
(author)
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Vineis, PaoloImperial College London
(author)
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Slimani, NadiaInternational Agency for Research on Cancer, World Health Organization
(author)
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International Agency for Research on Cancer, World Health OrganizationImperial College London
(creator_code:org_t)
Related titles
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In:International Journal of Cancer: John Wiley & Sons144:7, s. 1511-15210020-71361097-0215
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Park, Jin Young
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Bueno-de-Mesquit ...
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Ferrari, Pietro
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Weiderpass, Elis ...
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de Batlle, Jordi
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Tjonneland, Anne
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Kyro, Cecilie
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Rebours, Vincian ...
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Boutron-Ruault, ...
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Mancini, Frances ...
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Katzke, Verena
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Kuehn, Tilman
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Boeing, Heiner
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Trichopoulou, An ...
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La Vecchia, Carl ...
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Kritikou, Maria
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Masala, Giovanna
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Pala, Valeria
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Tumino, Rosario
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Panico, Salvator ...
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Peeters, Petra H ...
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Skeie, Guri
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Merino, Susana
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Duell, Eric J.
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Rodriguez-Barran ...
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Dorronsoro, Mire ...
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Chirlaque, Maria ...
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Ardanaz, Eva
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Gylling, Björn, ...
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Schneede, Jörn
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Ericson, Ulrika
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Sternby, Hanna
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Khaw, Kay-Tee
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Bradbury, Kathry ...
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Huybrechts, Inge
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Aune, Dagfinn
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Vineis, Paolo
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Slimani, Nadia
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Umeå University
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Karolinska Institutet
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Lund University