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Predicting Circulat...
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Sasamoto, NaokoHarvard University,Brigham and Women's Hospital / Harvard Medical School
(författare)
Predicting Circulating CA125 Levels among Healthy Premenopausal Women
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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American Association for Cancer Research (AACR),2019
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-162894
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162894URI
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https://doi.org/10.1158/1055-9965.EPI-18-1120DOI
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https://lup.lub.lu.se/record/4e7266cb-2f70-42de-a179-2a7be8896589URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141651012URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Cancer antigen 125 (CA125) is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Methods: We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study (NEC). We developed linear and dichotomous (>= 35 U/mL) CA125 prediction models and externally validated an abridged model restricting to available predictors among 473 premenopausal women in the European Prospective Investigation into Cancer and Nutrition Study (EPIC). Results: The final linear CA125 prediction model included age, race, tubal ligation, endometriosis, menstrual phase at blood draw, and fibroids, which explained 7% of the total variance of CA125. The correlation between observed and predicted CA125 levels based on the abridged model (including age, race, and menstrual phase at blood draw) had similar correlation coefficients in NEC (r = 0.22) and in EPIC (r = 0.22). The dichotomous CA125 prediction model included age, tubal ligation, endometriosis, prior personal cancer diagnosis, family history of ovarian cancer, number of miscarriages, menstrual phase at blood draw, and smoking status with AUC of 0.83. The abridged dichotomous model (including age, number of miscarriages, menstrual phase at blood draw, and smoking status) showed similar AUCs in NEC (0.73) and in EPIC (0.78). Conclusions: We identified a combination of factors associated with CA125 levels in premenopausal women. Impact: Our model could be valuable in identifying healthy women likely to have elevated CA125 and consequently improve its specificity for ovarian cancer screening.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Babic, AnaBrigham and Women's Hospital / Harvard Medical School,Harvard University,Dana-Farber Cancer Institute
(författare)
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Rosner, Bernard A.Harvard University,Brigham and Women's Hospital / Harvard Medical School
(författare)
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Fortner, Renee T.German Cancer Research Centre
(författare)
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Vitonis, Allison F.Brigham and Women's Hospital / Harvard Medical School
(författare)
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Yamamoto, HidemiBrigham and Women's Hospital / Harvard Medical School
(författare)
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Fichorova, Raina N.Harvard University,Brigham and Women's Hospital / Harvard Medical School
(författare)
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Tjonneland, AnneDanish Cancer Society
(författare)
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Hansen, LouiseDanish Cancer Society
(författare)
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Overvad, KimAarhus University
(författare)
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Kvaskoff, MarinaUniversity of Paris-Saclay
(författare)
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Fournier, AgnesUniversity of Paris-Saclay
(författare)
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Mancini, Francesca RomanaUniversity of Paris-Saclay
(författare)
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Boeing, HeinerGerman Institute of Human Nutrition
(författare)
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Trichopoulou, AntoniaNational and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
(författare)
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Peppa, EleniHellenic Health Foundation, Athens
(författare)
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Karakatsani, AnnaNational and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
(författare)
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Palli, DomenicoInstitute for Cancer Research, Prevention and Clinical Network (ISPRO)
(författare)
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Pala, ValeriaIstituto Nazionale dei Tumori
(författare)
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Mattiello, AmaliaUniversity of Naples Federico II
(författare)
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Tumino, RosarioCivic and M.P Arezzo Hospital
(författare)
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Grasso, Chiara C.University of Turin
(författare)
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Onland-Moret, N. CharlotteUniversity Medical Center Utrecht
(författare)
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Weiderpass, ElisabeteKarolinska Institutet,University of Helsinki,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø
(författare)
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Ramon Quiros, J.Public Health Directorate
(författare)
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Lujan-Barroso, LeilaBellvitge University Hospital-IDIBELL
(författare)
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Rodriguez-Barranco, MiguelCIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)
(författare)
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Colorado-Yohar, SandraUniversity of Antioquia,Murcia Regional Health Council
(författare)
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Barricarte, AurelioHealth Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
(författare)
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Dorronsoro, MirenCIBER Epidemiology and Public Health (CIBERESP)
(författare)
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Idahl, Annika,1965-Umeå University,Umeå universitet,Obstetrik och gynekologi,Näringsforskning(Swepub:umu)anid0002
(författare)
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Lundin, EvaUmeå University,Umeå universitet,Patologi(Swepub:umu)evlu0001
(författare)
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Sartor, HannaLund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-hso
(författare)
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Khaw, Kay-TeeUniversity of Cambridge
(författare)
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Key, Timothy J.University of Oxford
(författare)
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Muller, DavidImperial College London
(författare)
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Riboli, ElioInternational Agency for Research on Cancer, World Health Organization
(författare)
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Gunter, Marc J.International Agency for Research on Cancer, World Health Organization
(författare)
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Dossus, LaureInternational Agency for Research on Cancer, World Health Organization
(författare)
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Kaaks, RudolfGerman Cancer Research Centre
(författare)
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Cramer, Daniel W.Harvard University,Brigham and Women's Hospital / Harvard Medical School
(författare)
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Tworoger, Shelley S.H. Lee Moffitt Cancer Center & Research Institute
(författare)
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Terry, Kathryn L.Brigham and Women's Hospital / Harvard Medical School,Harvard University
(författare)
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Harvard UniversityBrigham and Women's Hospital / Harvard Medical School
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cancer Epidemiology, Biomarkers and Prevention: American Association for Cancer Research (AACR)28:6, s. 1076-10851055-99651538-7755
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Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Sasamoto, Naoko
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Babic, Ana
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Rosner, Bernard ...
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Fortner, Renee T ...
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Vitonis, Allison ...
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Yamamoto, Hidemi
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visa fler...
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Fichorova, Raina ...
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Tjonneland, Anne
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Hansen, Louise
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Overvad, Kim
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Kvaskoff, Marina
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Fournier, Agnes
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Mancini, Frances ...
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Boeing, Heiner
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Trichopoulou, An ...
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Peppa, Eleni
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Karakatsani, Ann ...
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Palli, Domenico
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Pala, Valeria
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Mattiello, Amali ...
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Tumino, Rosario
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Grasso, Chiara C ...
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Onland-Moret, N. ...
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Weiderpass, Elis ...
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Ramon Quiros, J.
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Lujan-Barroso, L ...
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Rodriguez-Barran ...
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Colorado-Yohar, ...
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Barricarte, Aure ...
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Dorronsoro, Mire ...
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Idahl, Annika, 1 ...
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Lundin, Eva
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Sartor, Hanna
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Khaw, Kay-Tee
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Key, Timothy J.
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Muller, David
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Riboli, Elio
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Gunter, Marc J.
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Dossus, Laure
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Kaaks, Rudolf
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Cramer, Daniel W ...
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Tworoger, Shelle ...
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Terry, Kathryn L ...
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visa färre...
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Umeå universitet
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