Search: onr:"swepub:oai:DiVA.org:umu-162898" >
Elevated Platelet C...
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Zhu, YingNanjing Medical University
(author)
Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer : A Mendelian Randomization Analysis
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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American Association for Cancer Research (AACR),2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-162898
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162898URI
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https://doi.org/10.1158/1055-9965.EPI-18-0356DOI
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https://lup.lub.lu.se/record/d77d5117-30e6-4646-a65f-3a1d75c721faURI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. Methods: We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk. Results: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall nonsmall cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15-2.27; P = 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27-7.06; P = 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings. Conclusions: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention. Impact: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Wei, Yongyue
(author)
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Zhang, Ruyang
(author)
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Dong, Xuesi
(author)
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Shen, Sipeng
(author)
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Zhao, Yang
(author)
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Bai, Jianling
(author)
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Albanes, Demetrius
(author)
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Caporaso, Neil E.
(author)
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Landi, Maria Teresa
(author)
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Zhu, Bin
(author)
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Chanock, Stephen J.
(author)
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Gu, Fangyi
(author)
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Lam, Stephen
(author)
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Tsao, Ming-Sound
(author)
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Shepherd, Frances A.
(author)
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Tardon, Adonina
(author)
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Fernandez-Somoano, Ana
(author)
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Fernandez-Tardon, Guillermo
(author)
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Chen, ChuHarvard University,Nanjing Medical University
(author)
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Barnett, Matthew J.
(author)
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Doherty, Jennifer
(author)
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Bojesen, Stig E.
(author)
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Johansson, Mattias
(author)
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Brennan, Paul
(author)
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Mckay, James D.
(author)
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Carreras-Torres, Robert
(author)
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Muley, Thomas
(author)
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Risch, Angela
(author)
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Wichmann, Heunz-Erich
(author)
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Bickeboeller, Heike
(author)
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Rosenberger, Albert
(author)
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Rennert, Gad
(author)
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Saliba, Walid
(author)
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Arnold, Susanne M.
(author)
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Field, John K.
(author)
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Davies, Michael P. A.
(author)
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Marcus, Michael W.
(author)
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Wu, Xifeng
(author)
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Ye, Yuanqing
(author)
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Le Marchand, Loic
(author)
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Wilkens, Lynne R.
(author)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(author)
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Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)smi-jma
(author)
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Brunnström, HansLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups(Swepub:lu)med-hsb
(author)
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Hung, Rayjean J.
(author)
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Liu, Geoffrey
(author)
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Brhane, Yonathan
(author)
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Kachuri, Linda
(author)
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Andrew, Angeline S.
(author)
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Duell, Eric J.
(author)
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Kiemeney, Lambertus A.
(author)
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van der Heijden, Erik H. F. M.
(author)
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Haugen, Aage
(author)
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Zienolddiny, Shanbeh
(author)
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Skaug, Vidar
(author)
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Grankvist, KjellUmeå universitet,Klinisk kemi(Swepub:umu)kjgr0002
(author)
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Johansson, MikaelUmeå universitet,Onkologi
(author)
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Woll, Penella J.
(author)
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Cox, Angela
(author)
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Taylor, Fiona
(author)
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Teare, Dawn M.
(author)
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Lazarus, Philip
(author)
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Schabath, Matthew B.
(author)
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Aldrich, Melinda C.
(author)
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Houlston, Richard S.
(author)
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McLaughlin, John
(author)
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Stevens, Victoria L.
(author)
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Shen, Hongbing
(author)
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Hu, Zhibin
(author)
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Dai, Juncheng
(author)
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Amos, Christopher I.
(author)
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Han, Younghun
(author)
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Zhu, Dakai
(author)
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Goodman, Gary E.
(author)
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Chen, Feng
(author)
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Christiani, David C.
(author)
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Nanjing Medical UniversityHarvard University
(creator_code:org_t)
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et al.
Related titles
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In:Cancer Epidemiology, Biomarkers and Prevention: American Association for Cancer Research (AACR)28:5, s. 935-9421055-99651538-7755
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- By the author/editor
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Zhu, Ying
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Wei, Yongyue
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Zhang, Ruyang
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Dong, Xuesi
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Shen, Sipeng
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Zhao, Yang
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show more...
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Bai, Jianling
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Albanes, Demetri ...
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Caporaso, Neil E ...
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Landi, Maria Ter ...
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Zhu, Bin
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Chanock, Stephen ...
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Gu, Fangyi
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Lam, Stephen
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Tsao, Ming-Sound
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Shepherd, France ...
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Tardon, Adonina
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Fernandez-Somoan ...
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Fernandez-Tardon ...
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Chen, Chu
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Barnett, Matthew ...
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Doherty, Jennife ...
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Bojesen, Stig E.
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Johansson, Matti ...
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Brennan, Paul
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Mckay, James D.
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Carreras-Torres, ...
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Muley, Thomas
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Risch, Angela
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Wichmann, Heunz- ...
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Bickeboeller, He ...
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Rosenberger, Alb ...
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Rennert, Gad
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Saliba, Walid
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Arnold, Susanne ...
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Field, John K.
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Davies, Michael ...
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Marcus, Michael ...
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Wu, Xifeng
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Ye, Yuanqing
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Le Marchand, Loi ...
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Wilkens, Lynne R ...
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Melander, Olle
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Manjer, Jonas
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Brunnström, Hans
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Hung, Rayjean J.
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Liu, Geoffrey
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Brhane, Yonathan
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Kachuri, Linda
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Andrew, Angeline ...
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Duell, Eric J.
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Kiemeney, Lamber ...
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van der Heijden, ...
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Haugen, Aage
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Zienolddiny, Sha ...
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Skaug, Vidar
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Grankvist, Kjell
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Johansson, Mikae ...
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Woll, Penella J.
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Cox, Angela
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Taylor, Fiona
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Teare, Dawn M.
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Lazarus, Philip
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Schabath, Matthe ...
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Aldrich, Melinda ...
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Houlston, Richar ...
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McLaughlin, John
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Stevens, Victori ...
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Shen, Hongbing
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Hu, Zhibin
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Dai, Juncheng
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Amos, Christophe ...
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Han, Younghun
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Zhu, Dakai
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Goodman, Gary E.
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Chen, Feng
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Christiani, Davi ...
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Cancer Epidemiol ...
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Umeå University
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Lund University