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Traffic-Related Air...
Traffic-Related Air Pollution as a Risk Factor for Dementia : No Clear Modifying Effects of APOEɛ4 in the Betula Cohort
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- Oudin, Anna (author)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för hållbar hälsa,Department of Laboratory Medicine, Lund University, Lund, Sweden.,Arbetsorganisation och hälsa,Forskargrupper vid Lunds universitet,Planetär hälsa,Environmental health and occupational health,Lund University Research Groups,Planetary Health
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- Andersson, John (author)
- Umeå University,Umeå universitet,Institutionen för psykologi
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- Sundström, Anna (author)
- Umeå universitet,Institutionen för psykologi
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- Nordin Adolfsson, Annelie (author)
- Umeå University,Umeå universitet,Psykiatri
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- Oudin Åström, Daniel (author)
- Umeå University,Umeå universitet,Avdelningen för hållbar hälsa
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- Adolfsson, Rolf (author)
- Umeå University,Umeå universitet,Psykiatri
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- Forsberg, Bertil (author)
- Umeå University,Umeå universitet,Avdelningen för hållbar hälsa
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- Nordin, Maria (author)
- Umeå University,Umeå universitet,Institutionen för psykologi
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(creator_code:org_t)
- IOS Press, 2019
- 2019
- English.
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In: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 71:3, s. 733-740
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- It is widely known that the apolipoprotein E (APOE) ɛ4 allele imposes a higher risk for Alzheimer’s disease (AD). Recent evidence suggests that exposure to air pollution is also a risk factor for AD, and results from a few studies indicate that the effect of air pollution on cognitive function and dementia is stronger in APOE ɛ4 carriers than in non-carriers. Air pollution and interaction with APOE ɛ4 on AD risk thus merits further attention. We studied dementia incidence over a 15-year period from the longitudinal Betula study in Northern Sweden. As a marker for long-term exposure to traffic-related air pollution, we used modelled annual mean nitrogen oxide levels at the residential address of the participants at start of follow-up. Nitrogen oxide correlate well with fine particulate air pollution levels in the study area. We had full data on air pollution, incidence of AD and vascular dementia (VaD), APOE ɛ4 carrier status, and relevant confounding factors for 1,567 participants. As expected, air pollution was rather clearly associated with dementia incidence. However, there was no evidence for a modifying effect by APOE ɛ4 on the association (p-value for interaction > 0.30 for both total dementia (AD+VaD) and AD). The results from this study do not imply that adverse effects of air pollution on dementia incidence is limited to, or stronger in, APOE ɛ4 carriers than in the total population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Air pollution
- Alzheimer’s disease
- apolipoprotein E
- dementia
Publication and Content Type
- ref (subject category)
- art (subject category)
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