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The Malaria Cell At...
The Malaria Cell Atlas : Single parasite transcriptomes across the complete Plasmodium life cycle
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Howick, Virginia M. (author)
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Russell, Andrew J. C. (author)
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Andrews, Tallulah (author)
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Heaton, Haynes (author)
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Reid, Adam J. (author)
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Natarajan, Kedar (author)
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Butungi, Hellen (author)
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Metcalf, Tom (author)
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Verzier, Lisa H. (author)
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Rayner, Julian C. (author)
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Berriman, Matthew (author)
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Herren, Jeremy K. (author)
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- Billker, Oliver (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK
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Hemberg, Martin (author)
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Talman, Arthur M. (author)
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Lawniczak, Mara K. N. (author)
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(creator_code:org_t)
- American Association for the Advancement of Science, 2019
- 2019
- English.
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In: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 365:6455
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We profiled the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire Plasmodium berghei life cycle. We then used our atlas to precisely define developmental stages of single cells from three different human malaria parasite species, including parasites isolated directly from infected individuals. The Malaria Cell Atlas provides both a comprehensive view of gene usage in a eukaryotic parasite and an open-access reference dataset for the study of malaria parasites.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Howick, Virginia ...
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Russell, Andrew ...
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Andrews, Tallula ...
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Heaton, Haynes
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Reid, Adam J.
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Natarajan, Kedar
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show more...
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Butungi, Hellen
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Metcalf, Tom
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Verzier, Lisa H.
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Rayner, Julian C ...
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Berriman, Matthe ...
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Herren, Jeremy K ...
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Billker, Oliver
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Hemberg, Martin
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Talman, Arthur M ...
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Lawniczak, Mara ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Science
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Umeå University