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Concomitant Ro/SSA ...
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Mofors, J.Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden
(author)
Concomitant Ro/SSA and La/SSB antibodies are biomarkers for the risk of venous thromboembolism and cerebral infarction in primary Sjögren's syndrome
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-06-17
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John Wiley & Sons,2019
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-164032
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164032URI
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https://doi.org/10.1111/joim.12941DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-395731URI
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https://lup.lub.lu.se/record/27323e96-f084-4c65-9ed2-68c4c5907b08URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-160986URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141917157URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Heart-Lung FoundationSwedish Heart-Lung Foundation; Karolinska InstituteKarolinska Institutet; Stockholm County CouncilStockholm County Council; Swedish Research CouncilSwedish Research Council; Swedish Rheumatism Association; King Gustaf the V:th 80-year Foundation
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Background: To assess the risk of incident cardiovascular disease in patients with primary Sjögren's syndrome, overall and stratified by Ro/SSA and La/SSB autoantibody status.Methods: A cohort of patients with primary Sjögren's syndrome in Sweden (n = 960) and matched controls from the general population (n = 9035) were included, and data extracted from the National Patient Register to identify events of myocardial infarction, cerebral infarction and venous thromboembolism. Hazard ratios were estimated using cox proportional hazard regressions.Results: During a median follow‐up of 9.5 years, the overall hazard ratio (HR) was 1.6 (95% CI 1.2–2.1) for myocardial infarction, 1.2 (95% CI 0.9–1.7) for cerebral infarction and 2.1 (95% CI 1.6–2.9) for venous thromboembolism. Patients positive for both Ro/SSA and La/SSB autoantibodies had a substantially higher risk of cerebral infarction (HR 1.7, 95% CI 1.0–2.9) and venous thromboembolism (HR 3.1, 95% CI 1.9–4.8) than the general population. These risks were not significantly increased in Ro/SSA‐ and La/SSB‐negative patients. Among autoantibody‐positive patients, the highest HR of cerebral infarction was seen after ≥10 years disease duration (HR 2.8, 95% CI 1.4–5.4), while the HR for venous thromboembolism was highest 0–5 years after disease diagnosis (HR 4.7, 95% CI 2.3–9.3) and remained high throughout disease duration.Conclusions: Primary Sjögren's syndrome is associated with a markedly increased risk of cardiovascular disease and the presence of Ro/SSA and La/SSB autoantibodies identify the subgroup of patients carrying the highest risk. These findings suggest that monitoring and prevention of cardiovascular disease in this patient group should be considered.
Subject headings and genre
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Holmqvist, M.Karolinska Institutet
(author)
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Westermark, L.Uppsala University,Uppsala universitet,Reumatologi,Uppsala Univ, Sweden
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Björk, A.Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden
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Kvarnström, M.Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden
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Forsblad-d'Elia, HelenaUmeå University,Umeå universitet,Reumatologi,Umea Univ, Dept Publ Hlth & Clin Med, Rheumatol, Umea, Sweden(Swepub:umu)hefo0034
(author)
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Bucher, S. MagnussonÖrebro University,Orebro Univ, Sweden
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Eriksson, PerLinköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)perer22
(author)
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Theander, ElkeLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)medf-eth
(author)
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Mandl, ThomasLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)medf-tma
(author)
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Wahren-Herlenius, M.Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden
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Nordmark, GunnelUppsala University,Uppsala universitet,Reumatologi,Uppsala Univ, Sweden(Swepub:uu)gunnnord
(author)
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Karolinska InstituteKarolinska Univ Hosp, Sweden
(creator_code:org_t)
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In:Journal of Internal Medicine: John Wiley & Sons286:4, s. 458-4680954-68201365-2796
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Mofors, J.
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Holmqvist, M.
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Westermark, L.
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Björk, A.
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Kvarnström, M.
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Forsblad-d'Elia, ...
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Bucher, S. Magnu ...
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Eriksson, Per
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Theander, Elke
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Mandl, Thomas
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Wahren-Herlenius ...
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Nordmark, Gunnel
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Umeå University
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Uppsala University
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Linköping University
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Karolinska Institutet