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  • Mofors, J.Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden (author)

Concomitant Ro/SSA and La/SSB antibodies are biomarkers for the risk of venous thromboembolism and cerebral infarction in primary Sjögren's syndrome

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-06-17
  • John Wiley & Sons,2019
  • electronicrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:umu-164032
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164032URI
  • https://doi.org/10.1111/joim.12941DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-395731URI
  • https://lup.lub.lu.se/record/27323e96-f084-4c65-9ed2-68c4c5907b08URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-160986URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141917157URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Heart-Lung FoundationSwedish Heart-Lung Foundation; Karolinska InstituteKarolinska Institutet; Stockholm County CouncilStockholm County Council; Swedish Research CouncilSwedish Research Council; Swedish Rheumatism Association; King Gustaf the V:th 80-year Foundation
  • Background: To assess the risk of incident cardiovascular disease in patients with primary Sjögren's syndrome, overall and stratified by Ro/SSA and La/SSB autoantibody status.Methods: A cohort of patients with primary Sjögren's syndrome in Sweden (n = 960) and matched controls from the general population (n = 9035) were included, and data extracted from the National Patient Register to identify events of myocardial infarction, cerebral infarction and venous thromboembolism. Hazard ratios were estimated using cox proportional hazard regressions.Results: During a median follow‐up of 9.5 years, the overall hazard ratio (HR) was 1.6 (95% CI 1.2–2.1) for myocardial infarction, 1.2 (95% CI 0.9–1.7) for cerebral infarction and 2.1 (95% CI 1.6–2.9) for venous thromboembolism. Patients positive for both Ro/SSA and La/SSB autoantibodies had a substantially higher risk of cerebral infarction (HR 1.7, 95% CI 1.0–2.9) and venous thromboembolism (HR 3.1, 95% CI 1.9–4.8) than the general population. These risks were not significantly increased in Ro/SSA‐ and La/SSB‐negative patients. Among autoantibody‐positive patients, the highest HR of cerebral infarction was seen after ≥10 years disease duration (HR 2.8, 95% CI 1.4–5.4), while the HR for venous thromboembolism was highest 0–5 years after disease diagnosis (HR 4.7, 95% CI 2.3–9.3) and remained high throughout disease duration.Conclusions: Primary Sjögren's syndrome is associated with a markedly increased risk of cardiovascular disease and the presence of Ro/SSA and La/SSB autoantibodies identify the subgroup of patients carrying the highest risk. These findings suggest that monitoring and prevention of cardiovascular disease in this patient group should be considered.

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  • Holmqvist, M.Karolinska Institutet (author)
  • Westermark, L.Uppsala University,Uppsala universitet,Reumatologi,Uppsala Univ, Sweden (author)
  • Björk, A.Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden (author)
  • Kvarnström, M.Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden (author)
  • Forsblad-d'Elia, HelenaUmeå University,Umeå universitet,Reumatologi,Umea Univ, Dept Publ Hlth & Clin Med, Rheumatol, Umea, Sweden(Swepub:umu)hefo0034 (author)
  • Bucher, S. MagnussonÖrebro University,Orebro Univ, Sweden (author)
  • Eriksson, PerLinköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)perer22 (author)
  • Theander, ElkeLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)medf-eth (author)
  • Mandl, ThomasLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)medf-tma (author)
  • Wahren-Herlenius, M.Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Sweden (author)
  • Nordmark, GunnelUppsala University,Uppsala universitet,Reumatologi,Uppsala Univ, Sweden(Swepub:uu)gunnnord (author)
  • Karolinska InstituteKarolinska Univ Hosp, Sweden (creator_code:org_t)

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  • In:Journal of Internal Medicine: John Wiley & Sons286:4, s. 458-4680954-68201365-2796

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