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Comprehensive evalu...
Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer
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- Johansson, Mattias (author)
- Umeå universitet,Urologi och andrologi
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McKay, James D (author)
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- Stattin, Pär (author)
- Umeå universitet,Urologi och andrologi
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Canzian, Federico (author)
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Boillot, Catherine (author)
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- Wiklund, Fredrik (author)
- Karolinska Institutet,Umeå universitet,Onkologi
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- Adami, Hans-Olov (author)
- Karolinska Institutet
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- Bälter, Katarina (author)
- Karolinska Institutet
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- Grönberg, Henrik (author)
- Karolinska Institutet
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Kaaks, Rudolf (author)
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(creator_code:org_t)
- 2006
- 2007
- English.
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In: International Journal of Cancer. - German Canc Res Ctr, Div Canc Epidemiol, DKFZ, D-69121 Heidelberg, Germany. Umea Univ Hosp, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umea, Sweden. Int Agcy Res Canc, F-69372 Lyon, France. Menzies Res Inst, Hobart, Tas, Australia. German Canc Inst, Genom Epidemiol Grp, DKFZ, Heidelberg, Germany. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. Harvard Univ, Dept Epidemiol, Boston, MA 02115 USA. : Wiley. - 0020-7136 .- 1097-0215. ; 120:3, s. 539-542
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Abstract
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- Insulin-like growth factor-I (IGF1) stimulates cell proliferation, decreases apoptosis, and has been implicated in cancer development. Epidemiological studies have shown elevated levels of circulating IGF1 to be associated with increased risk of prostate cancer. To what extent genetic variation in the IGF1 gene is related to prostate cancer risk is largely unknown. We performed a comprehensive haplotype tagging (HT) assessment of single nucleotide polymorphisms (SNPs) representing the common haplotype variation in the IGF1 gene. We genotyped 10 SNPs (9 haplotype tagging SNPs (htSNPs)) within Cancer Prostate in Sweden (CAPS), a case–control study of 2,863 cases and 1,737 controls, in order to investigate if genetic variation in the IGF1 gene is associated with prostate cancer risk. Three haplotype blocks were identified across the IGF1 gene and 9 SNPs were selected as haplotype tagging SNPs. Common haplotypes in the block covering the 3′ region of the IGF1 gene showed significant global association with prostate cancer risk (p = 0.004), with one particular haplotype giving an odds ratio of 1.46 (95% CI = 1.15–1.84, p = 0.002). This haplotype had a prevalence of 5% in the study population. Our results indicate that common variation in the IGF1 gene, particularly in the 3′ region, may affect prostate cancer risk. Further studies on genetic variations in the IGF1 gene in relation to prostate cancer risk as well as to circulating levels of IGF1 are needed to confirm this novel finding.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Keyword
- IGF1
- prostate cancer
- single nucleotide polymorphism
- haplotype
- block
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Johansson, Matti ...
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McKay, James D
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Stattin, Pär
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Canzian, Federic ...
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Boillot, Catheri ...
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Wiklund, Fredrik
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show more...
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Adami, Hans-Olov
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Bälter, Katarina
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Grönberg, Henrik
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Kaaks, Rudolf
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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International Jo ...
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Umeå University
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Mälardalen University
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Karolinska Institutet