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  • Arouca, Aline B (author)

Interplay between the Mediterranean diet and C-reactive protein genetic polymorphisms towards inflammation in adolescents

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Churchill Livingstone,2020
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:umu-164179
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164179URI
  • https://doi.org/10.1016/j.clnu.2019.08.016DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143793800URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • AIM: From a nutrigenetics perspective, we aim to investigate the moderating role of the Mediterranean diet and each of its subgroups in the association between C-reactive protein (CRP) gene polymorphisms and CRP blood concentration in adolescents.METHODS: In 562 adolescents (13-17 y) of the European HELENA study, data was available on circulating CRP levels as inflammatory biomarker, three CRP gene SNPs (rs3093068, rs1204, rs1130864), food intake determined by a self-administered computerized 24 h-dietary recall for 2 days, and body composition. A 9-point Mediterranean diet score and each food subgroup were tested as moderator via SNP*diet interaction. Analyzes were adjusted for age, sex, puberty, adiposity and socioeconomic status.RESULTS: The minor allele frequencies of rs3093068 and rs1130864 SNPs (GG and TT, respectively) were associated with higher CRP concentrations, while rs1205 (CT/TT) was associated with lower CRP concentrations. There were significant interactions between rs3093068 and Mediterranean diet (B = -0.1139, p = 0.011), or the fish food subgroup (B = -0.0090, p = 0.022), so that those with the highest genetic CRP risk underwent the highest CRP attenuation by a healthier diet. Although the effect of diet and SNP was substantial, the explained variance by interaction was only 1%.CONCLUSION: Greater adherence to the Mediterranean diet and particularly its fish component was associated with a lower CRP blood concentrations especially in those at highest genetic risk due to the rs3093068 SNP.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Meirhaeghe, Aline (author)
  • Dallongeville, Jean (author)
  • Moreno, Luis A (author)
  • Lourenço, Gustavo Jacob (author)
  • Marcos, Ascensión (author)
  • Huybrechts, Inge (author)
  • Manios, Yannis (author)
  • Lambrinou, Christina-Paulina (author)
  • Gottrand, Frederic (author)
  • Kafatos, Anthony (author)
  • Kersting, Mathilde (author)
  • Sjöström, MichaelKarolinska Institutet (author)
  • Widhalm, Kurt (author)
  • Ferrari, Marika (author)
  • Molnár, Denes (author)
  • González-Gross, Marcela (author)
  • Forsner, Maria,1954-Karolinska Institutet,Umeå universitet,Institutionen för omvårdnad(Swepub:umu)maafor73 (author)
  • De Henauw, Stefaan (author)
  • Michels, Nathalie (author)
  • Karolinska InstitutetInstitutionen för omvårdnad (creator_code:org_t)

Related titles

  • In:Clinical Nutrition: Churchill Livingstone39:6, s. 1919-19260261-56141532-1983

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