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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003853naa a2200445 4500
001oai:DiVA.org:umu-164387
003SwePub
008191112s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1643872 URI
0247 a https://doi.org/10.1530/EJE-19-01612 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Crawford, Andrew A.4 aut
2451 0a Morning plasma cortisol as a cardiovascular risk factor :b findings from prospective cohort and Mendelian randomization studies
264 1b Bioscientifica,c 2019
338 a electronic2 rdacarrier
520 a Objective: The identification of new causal risk factors has the potential to improve cardiovascular disease (CVD) risk prediction and the development of new treatments to reduce CVD deaths. In the general population, we sought to determine whether cortisol is a causal risk factor for CVD and coronary heart disease (CHD).Design and methods: Three approaches were adopted to investigate the association between cortisol and CVD/CHD. First, we used multivariable regression in two prospective nested case-control studies (total 798 participants, 313 incident CVD/CHD with complete data). Second, a random-effects meta-analysis of these data and previously published prospective associations was performed (total 6680 controls, 696 incident CVD/CHD). Finally, one- and two-sample Mendelian randomization analyses were performed (122,737 CHD cases, 547,261 controls for two-sample analyses).Results: In the two prospective nested case-control studies, logistic regression adjusting for sex, age, BMI, smoking and time of sampling, demonstrated a positive association between morning plasma cortisol and incident CVD (OR: 1.28 per 1 SD higher cortisol, 95% CI: 1.06-1.54). In the meta-analysis of prospective studies, the equivalent result was OR: 1.18, 95% CI: 1.06-1.31. Results from the two-sample Mendelian randomization were consistent with these positive associations: OR: 1.06, 95% Cl: 0.98-1.15.Conclusions: All three approaches demonstrated a positive association between morning plasma cortisol and incident CVD. Together, these findings suggest that elevated morning cortisol is a causal risk factor for CVD. The current data suggest strategies targeted at lowering cortisol action should be evaluated for their effects on CVD.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Söderberg, Stefanu Umeå universitet,Kardiologi4 aut0 (Swepub:umu)stso0001
7001 a Kirschbaum, Clemens4 aut
7001 a Murphy, Lee4 aut
7001 a Eliasson, Matsu Umeå universitet,Avdelningen för medicin,Sunderby Research Unit, Umeå University, Umeå, Sweden4 aut0 (Swepub:umu)mael0021
7001 a Ebrahim, Shah4 aut
7001 a Smith, George Davey4 aut
7001 a Olsson, Tommyu Umeå universitet,Avdelningen för medicin4 aut0 (Swepub:umu)tool0003
7001 a Sattar, Naveed4 aut
7001 a Lawlor, Debbie A.4 aut
7001 a Timpson, Nicolas J.4 aut
7001 a Reynolds, Rebecca M.4 aut
7001 a Walker, Brian R.4 aut
7102 a Umeå universitetb Kardiologi4 org
7730 t European Journal of Endocrinologyd : Bioscientificag 181:4, s. 429-438q 181:4<429-438x 0804-4643x 1479-683X
8564 u https://doi.org/10.1530/EJE-19-0161y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1369538/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164387
8564 8u https://doi.org/10.1530/EJE-19-0161

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