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Differential resist...
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Ruuth, KristinaUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Lundgren
(author)
Differential resistance of melanoma cells to treatment with recombinant IFN-alpha2b and leukocyte IFN.
- Article/chapterEnglish2007
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-16482
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-16482URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Interferon-alpha (IFN-alpha) subtypes bind to the same receptor and are expected to have the same biological functions. Whether or not leukocyte IFN, containing six major IFN-alpha proteins had the same anti-tumor effect as one subtype, recombinant IFN-alpha2b, was investigated. MATERIALS AND METHODS: Three melanoma lines were treated with both types of IFN, and the effect on proliferation and survival was estimated both after short-term and prolonged treatment. RESULTS: All the melanoma cell lines were sensitive to the antiproliferative effects of both IFN species during short-term treatment. However, upon prolonged culture, the frequency of resistant colony formation was significantly higher in cultures treated with IFN-alpha2b compared to those treated with leukocyte IFN. There was a qualitative difference between the resistant colonies selected by the two IFN species with respect to morphology, growth rate and sensitivity to apoptosis. CONCLUSION: The development of resistant clones occurred at a lower rate during long-term treatment with leukocyte IFN containing six major subtypes of IFN-alpha as compared to IFN-alpha2b.
Subject headings and genre
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Antineoplastic Agents/*pharmacology
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Cell Growth Processes/drug effects
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Drug Resistance; Neoplasm
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Humans
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Interferon Alfa-2b/*pharmacology
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Interferon-alpha/*pharmacology
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Melanoma/*drug therapy/pathology
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Tumor Cells; Cultured
Added entries (persons, corporate bodies, meetings, titles ...)
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Berglund, Asa
(author)
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Munoz, Varinia
(author)
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Lundgren, ErikUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Lundgren(Swepub:umu)erlu0003
(author)
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Umeå universitetInstitutionen för molekylärbiologi (Medicinska fakulteten)
(creator_code:org_t)
Related titles
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In:Anticancer Res27:4B, s. 2109-140250-7005
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