Virulence and Pathogenicity Properties of Aggregatibacter actinomycetemcomitans

• Aggregatibacter actinomycetemcomitans is a periodontal pathogen colonizing the oral cavity of a large proportion of the human population. It is equipped with several potent virulence factors that can cause cell death and induce or evade inflammation. Because of the large genetic diversity within the species, both harmless and highly virulent genotypes of the bacterium have emerged. The oral condition and age, as well as the geographic origin of the individual, influence the risk to be colonized by a virulent genotype of the bacterium. In the present review, the virulence and pathogenicity properties of A. actinomycetemcomitans will be addressed.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)

Keyword

Aggregatibacter actinomycetemcomitans

biofilm

cytokine binding factors

cytolethal distending toxin

horizontal gene transfer

leukotoxin

lipopolysaccharides

outer membrane vesicles

proteomic

Publication and Content Type

ref (subject category)

art (subject category)