Cutting edge: the membrane attack complex of complement is required for the development of murine experimental cerebral malaria

Cutting edge : the membrane attack complex of complement is required for the development of murine experimental cerebral malaria

Ramos, Theresa N (author)

Darley, Meghan M (author)

Hu, Xianzhen (author)

2011-06-15
2011
English.
In: Journal of Immunology. - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 186:12, s. 6657-6660

Related links:: http://www.jimmunol....; show more...; https://urn.kb.se/re...; https://doi.org/10.4...; show less...

Abstract Subject headings

Cerebral malaria is the most severe complication of Plasmodium falciparum infection and accounts for a large number of malaria fatalities worldwide. Recent studies demonstrated that C5(-/-) mice are resistant to experimental cerebral malaria (ECM) and suggested that protection was due to loss of C5a-induced inflammation. Surprisingly, we observed that C5aR(-/-) mice were fully susceptible to disease, indicating that C5a is not required for ECM. C3aR(-/-) and C3aR(-/-) × C5aR(-/-) mice were equally susceptible to ECM as were wild-type mice, indicating that neither complement anaphylatoxin receptor is critical for ECM development. In contrast, C9 deposition in the brains of mice with ECM suggested an important role for the terminal complement pathway. Treatment with anti-C9 Ab significantly increased survival time and reduced mortality in ECM. Our data indicate that protection from ECM in C5(-/-) mice is mediated through inhibition of membrane attack complex formation and not through C5a-induced inflammation.

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

By the author/editor: Ramos, Theresa N; Darley, Meghan M; Hu, Xianzhen; Billker, Oliver; Rayner, Julian C; Ahras, Malika; show more...; Wohler, Jillian ...; Barnum, Scott R; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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