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- Vikner, TomasUmeå universitet,Radiofysik (author)
Characterizing pulsatility in distal cerebral arteries using 4D flow MRI
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- Sage Publications,2020
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-166582
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-166582URI
- https://doi.org/10.1177/0271678X19886667DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Recent reports have suggested that age-related arterial stiffening and excessive cerebral arterial pulsatility cause blood-brain barrier breakdown, brain atrophy and cognitive decline. This has spurred interest in developing non-invasive methods to measure pulsatility in distal vessels, closer to the cerebral microcirculation. Here, we report a method based on four-dimensional (4D) flow MRI to estimate a global composite flow waveform of distal cerebral arteries. The method is based on finding and sampling arterial waveforms from thousands of cross sections in numerous small vessels of the brain, originating from cerebral cortical arteries. We demonstrate agreement with internal and external reference methods and show the ability to capture significant increases in distal cerebral arterial pulsatility as a function of age. The proposed approach can be used to advance our understanding regarding excessive arterial pulsatility as a potential trigger of cognitive decline and dementia.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
- 4D flow MRI
- cerebral hemodynamics
- arterial pulsatility
- cerebral cortical arteries
- aging
Added entries (persons, corporate bodies, meetings, titles ...)
- Nyberg, Lars,1966-Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)lany0001 (author)
- Holmgren, MadeleneUmeå universitet,Radiofysik(Swepub:umu)maho0149 (author)
- Malm, Jan,Professor,1957-Umeå universitet,Klinisk neurovetenskap(Swepub:umu)jama0002 (author)
- Eklund, Anders,1965-Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)anek0025 (author)
- Wåhlin, AndersUmeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)arswan02 (author)
- Umeå universitetRadiofysik (creator_code:org_t)
Related titles
- In:Journal of Cerebral Blood Flow and Metabolism: Sage Publications40:12, s. 2429-24400271-678X1559-7016
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