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Globus pallidal dee...
Globus pallidal deep brain stimulation for Tourette syndrome : Effects on cognitive function
- Article/chapterEnglish2019
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Elsevier,2019
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LIBRIS-ID:oai:DiVA.org:umu-167062
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-167062URI
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https://doi.org/10.1016/j.parkreldis.2019.10.013DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Introduction: In a double-blind randomized crossover trial, we previously established that bilateral deep brain stimulation of the anteromedial globus pallidus internus (GPiam-DBS) is effective in significantly reducing tic severity in patients with refractory Tourette syndrome (TS). Here, we report the effects of bilateral GPiam-DBS on cognitive function in 11 of the 13 patients who had participated in our double-blind cross-over trial of GPi-DBS.Methods: Patients were assessed at baseline (4 weeks prior to surgery) and at the end of each of the three-month blinded periods, with stimulation either ON or OFF. The patients were evaluated on tests of memory (California Verbal Learning Test-II (CVLT-II); Corsi blocks; Short Recognition Memory for Faces), executive function (D-KEFS Stroop color-word interference, verbal fluency, Trail-making test, Hayling Sentence Completion test), and attention (Paced Auditory Serial Addition Test, Numbers and Letters Test).Results: GPiam-DBS did not produce any significant change in global cognition. Relative to pre-operative baseline assessment verbal episodic memory on the CVLT-II and set-shifting on the Trail-making Test were improved with DBS OFF. Performance on the cognitive tests were not different with DBS ON versus DBS OFF. GPiam-DBS did not alter aspects of cognition that are impaired in TS such as inhibition on the Stroop interference task or the Hayling Sentence Completion test.Conclusions: This study extends previous findings providing data showing that GPiam-DBS does not adversely affect cognitive domains such as memory, executive function, verbal fluency, attention, psychomotor speed, and information processing. These results indicate that GPiam-DBS does not produce any cognitive deficits in TS.
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Beigi, Mazda
(author)
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Kefalopoulou, Zinovia
(author)
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Zrinzo, Ludvic
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Candelario, Joseph
(author)
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Milabo, Catherine
(author)
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Akram, Harith
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Dayal, Viswas
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Hyam, Jonathan
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Kass-Iliyya, Lewis
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Silverdale, Monty
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Evans, Julian
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Limousin, Patricia
(author)
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Hariz, MarwanUmeå universitet,Klinisk neurovetenskap,Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK(Swepub:umu)hama0032
(author)
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Joyce, Eileen
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Foltynie, Thomas
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Jahanshahi, Marjan
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Umeå universitetKlinisk neurovetenskap
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In:Parkinsonism & Related Disorders: Elsevier69, s. 14-181353-80201873-5126
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Cappon, Davide
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Beigi, Mazda
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Kefalopoulou, Zi ...
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Zrinzo, Ludvic
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Akram, Harith
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Dayal, Viswas
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Hyam, Jonathan
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Kass-Iliyya, Lew ...
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Silverdale, Mont ...
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Evans, Julian
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Limousin, Patric ...
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Hariz, Marwan
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Joyce, Eileen
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Foltynie, Thomas
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Jahanshahi, Marj ...
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