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Globus pallidal dee...
Globus pallidal deep brain stimulation for Tourette syndrome : Effects on cognitive function
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Cappon, Davide (author)
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Beigi, Mazda (author)
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Kefalopoulou, Zinovia (author)
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Zrinzo, Ludvic (author)
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Candelario, Joseph (author)
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Milabo, Catherine (author)
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Akram, Harith (author)
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Dayal, Viswas (author)
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Hyam, Jonathan (author)
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Kass-Iliyya, Lewis (author)
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Silverdale, Monty (author)
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Evans, Julian (author)
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Limousin, Patricia (author)
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- Hariz, Marwan (author)
- Umeå universitet,Klinisk neurovetenskap,Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
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Joyce, Eileen (author)
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Foltynie, Thomas (author)
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Jahanshahi, Marjan (author)
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- English.
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In: Parkinsonism & Related Disorders. - : Elsevier. - 1353-8020 .- 1873-5126. ; 69, s. 14-18
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https://discovery.uc...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Introduction: In a double-blind randomized crossover trial, we previously established that bilateral deep brain stimulation of the anteromedial globus pallidus internus (GPiam-DBS) is effective in significantly reducing tic severity in patients with refractory Tourette syndrome (TS). Here, we report the effects of bilateral GPiam-DBS on cognitive function in 11 of the 13 patients who had participated in our double-blind cross-over trial of GPi-DBS.Methods: Patients were assessed at baseline (4 weeks prior to surgery) and at the end of each of the three-month blinded periods, with stimulation either ON or OFF. The patients were evaluated on tests of memory (California Verbal Learning Test-II (CVLT-II); Corsi blocks; Short Recognition Memory for Faces), executive function (D-KEFS Stroop color-word interference, verbal fluency, Trail-making test, Hayling Sentence Completion test), and attention (Paced Auditory Serial Addition Test, Numbers and Letters Test).Results: GPiam-DBS did not produce any significant change in global cognition. Relative to pre-operative baseline assessment verbal episodic memory on the CVLT-II and set-shifting on the Trail-making Test were improved with DBS OFF. Performance on the cognitive tests were not different with DBS ON versus DBS OFF. GPiam-DBS did not alter aspects of cognition that are impaired in TS such as inhibition on the Stroop interference task or the Hayling Sentence Completion test.Conclusions: This study extends previous findings providing data showing that GPiam-DBS does not adversely affect cognitive domains such as memory, executive function, verbal fluency, attention, psychomotor speed, and information processing. These results indicate that GPiam-DBS does not produce any cognitive deficits in TS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Tourette syndrome
- Deep brain stimulation
- Globus pallidus
- Cognitive function
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cappon, Davide
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Beigi, Mazda
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Kefalopoulou, Zi ...
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Zrinzo, Ludvic
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Candelario, Jose ...
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Milabo, Catherin ...
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show more...
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Akram, Harith
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Dayal, Viswas
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Hyam, Jonathan
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Kass-Iliyya, Lew ...
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Silverdale, Mont ...
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Evans, Julian
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Limousin, Patric ...
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Hariz, Marwan
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Joyce, Eileen
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Foltynie, Thomas
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Jahanshahi, Marj ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Parkinsonism & R ...
- By the university
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Umeå University