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A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex-associated Alzheimer's disease

Lopatko Lindman, Karin (author)
Umeå universitet,Geriatrik
Weidung, Bodil (author)
Umeå universitet,Geriatrik,Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden
Olsson, Jan (author)
Umeå universitet,Avdelningen för virologi
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Josefsson, Maria, 1979- (author)
Umeå universitet,Enheten för demografi och åldrandeforskning (CEDAR)
Kok, Eloise (author)
Johansson, Anders, 1955- (author)
Umeå universitet,Institutionen för odontologi,Avdelningen för hållbar hälsa,Aa-gruppen
Eriksson, Sture (author)
Umeå universitet,Geriatrik,Avdelningen för hållbar hälsa
Hallmans, Göran, 1947- (author)
Umeå universitet,Avdelningen för hållbar hälsa
Elgh, Fredrik, 1957- (author)
Umeå universitet,Avdelningen för virologi
Lövheim, Hugo, 1981- (author)
Umeå universitet,Geriatrik,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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 (creator_code:org_t)
2019-01
2019
English.
In: Alzheimer’s & Dementia. - : Wiley. - 2352-8737. ; 5, s. 697-704
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Introduction: Herpes simplex virus type 1 (HSV1) in combination with genetic susceptibility has previously been implicated in Alzheimer's disease (AD) pathogenesis.Methods: Plasma from 360 AD cases, obtained on average 9.6 years before diagnosis, and their age- and sex-matched controls, were analyzed for anti-HSV1 immunoglobulin (Ig) G with enzyme-linked immunosorbent assays (ELISAs). APOE genotype and nine other selected risk genes for AD were extracted from a genome-wide association study analysis by deCODE genetics, Reykjavik, Iceland.Results: The interaction between APOEε4 heterozygosity (APOEε2/ε4 or ε3/ε4) and anti-HSV1 IgG carriage increased the risk of AD (OR 4.55, P = .02). A genetic risk score based on the nine AD risk genes also interacted with anti-HSV1 IgG for the risk of developing AD (OR 2.35, P = .01).Discussion: The present findings suggest that the APOEε4 allele and other AD genetic risk factors might potentiate the risk of HSV1-associated AD.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Keyword

APOEε4
Alzheimer's disease
Apolipoprotein E4
Dementia
HSV
Herpes simplex
Nested case-control study
medicinsk virologi
Medical Virology

Publication and Content Type

ref (subject category)
art (subject category)

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