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In vitro percutaneo...
In vitro percutaneous penetration of topically applied capsaicin in relation to in vivo sensation responses
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- Magnusson, B.M. (author)
- Defence Research Establishment, Division of NBC Defence, Department of Biomedicine,Umeå, Sweden; Department of Public Health and Clinical Medicine, Section of Dermatology and Venerology, Umeå University Hospital, Umeå, Sweden
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- Koskinen, Lars-Owe D., Professor, 1955- (author)
- Umeå universitet,Neurokirurgi,Defence Research Establishment, Division of NBC Defence, Department of Biomedicine, Umeå, Sweden
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(creator_code:org_t)
- Elsevier BV, 2000
- 2000
- English.
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In: International Journal of Pharmaceutics. - : Elsevier BV. - 0378-5173 .- 1873-3476. ; 195:1-2, s. 55-62
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Capsaicin, the primary pungent element in several spices, elicits a variety of physiological effects which are due to neurogenic responses. The aim of the study was to explore the in vivo sensation responses of capsaicin and to compare the results with the in vitro percutaneous absorption of the substance. The overall objectives were to determining an in vitro-in vivo correlation for capsaicin. Capsaicin was applied in a chamber on the volar forearm of twelve volunteers and in a flow-through diffusion chamber on excised human epidermal membranes. Topical administration of capsaicin produced a complex cutaneous sensation that changed in intensity and quality as a function of time and was characterized by sting, prick, burn and pain. Percutaneous steady-state penetrations of capsaicin with a receptor fluid consisting either of 4% bovine serum albumin in phosphate buffered saline or 50% ethanol in water were 28.2+/-2.7 and 29.6+/-2.9 microg/cm(2) per h, respectively. The corresponding cumulative penetrated amounts of capsaicin after 30 min were 14. 7+/-1.7 and 19.2+/-2.1 microg/cm(2), respectively. The present investigation indicates that there is a good correlation between in vivo physiological responses and in vitro percutaneous penetration of topically applied capsaicin.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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