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Multicenter prospec...
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Van Damme, Pierre
(author)
Multicenter prospective study of the burden of rotavirus acute gastroenteritis in Europe, 2004-2005 : the REVEAL study.
- Article/chapterEnglish2007
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-16877
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-16877URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Rotavirus is recognized as a significant cause of pediatric gastroenteritis worldwide. Comprehensive data on the burden of rotavirus disease in Europe were lacking. METHODS: A prospective, multicenter, observational study was conducted during the 2004-2005 season in selected areas of Belgium, France, Germany, Italy, Spain, Sweden, and the United Kingdom, to estimate the incidence of acute gastroenteritis (AGE) and rotavirus gastroenteritis (RVGE) in children <5 years of age who require medical care in primary care, emergency department, and hospital settings. RESULTS: A total of 2846 children with AGE were included in the study, and, of the 2712 children for whom ELISA results were available, 1102 (40.6%) were found to be rotavirus positive. The estimated annual incidence of RVGE was 2.07-4.97 cases/100 children <5 years of age, and it was highest among children 6-23 months of age, with 56.7%-74.2% of all RVGE cases occurring in children in this age group. Overall, RVGE was estimated to account for 27.8%-52.0% of AGE cases, and it was responsible for up to two-thirds of hospitalizations and emergency department consultations, as well as one-third of primary care consultations for AGE. CONCLUSIONS: Rotavirus infections account for a significant proportion of AGE cases in children <5 years of age in Europe, many of whom require frequent primary care consultations or care in emergency department and/or hospital settings. The results of the present study suggest that routine rotavirus vaccination for infants <6 months of age could significantly reduce the substantial burden of this potentially serious childhood disease.
Subject headings and genre
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Rotavirus
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gastroenteritis
Added entries (persons, corporate bodies, meetings, titles ...)
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Giaquinto, Carlo
(author)
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Huet, Frederic
(author)
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Gothefors, LeifUmeå universitet,Pediatrik(Swepub:umu)lego0001
(author)
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Maxwell, Melanie
(author)
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Van der Wielen, Marie
(author)
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Umeå universitetPediatrik
(creator_code:org_t)
Related titles
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In:J Infect Dis195 Suppl 1, s. S4-S160022-1899
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