Leptin levels are not affected by enalapril treatment after an uncomplicated myocardial infarction, but associate strongly with changes in fibrinolytic variables in men

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Eriksson, Maria A.,1965-Umeå universitet,Avdelningen för medicin (author)

Leptin levels are not affected by enalapril treatment after an uncomplicated myocardial infarction, but associate strongly with changes in fibrinolytic variables in men

Article/chapterEnglish2020

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2020-03-03
Taylor & Francis,2020
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-169047
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169047URI
https://doi.org/10.1080/00365513.2020.1731848DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Leptin, an adipocyte-derived hormone, is involved in the regulation of body weight and is associated with obesity-related complications, notably cardiovascular disease (CVD). A putative link between obesity and CVD could be induction of plasminogen activator inhibitor-1 (PAI-1) synthesis by leptin. In this study, we hypothesized that the beneficial effect of the angiotensin-converting enzyme inhibitor (ACE(i)) enalapril on PAI-1 levels is mediated by effects on leptin levels. The association between leptin and components of the fibrinolytic system was evaluated in a non-prespecified post hoc analysis of a placebo-controlled randomized, double-blind trial where the effect of the ACE(i) enalapril on fibrinolysis was tested. A total of 46 men and 37 women were randomized to treatment with enalapril or placebo after (median 12 months) an uncomplicated myocardial infarction. At baseline, the participants were stable and had no signs of congestive heart failure. Leptin and fibrinolytic variables (mass concentrations of PAI-1, tissue plasminogen activator (tPA) and tPA-PAI complex) were measured at baseline, and after 10 days, 6 months and 12 months. Enalapril treatment did not change leptin levels, which increased significantly during 1 year of follow-up (p = .007). Changes in leptin levels were strongly associated with changes of tPA mass (p = .001), tPA-PAI complex (p = .003) and of PAI-1 (p = .006) in men, but not in women. Leptin levels are not influenced by treatment with an ACE(i). In contrast, leptin associates strongly with changes in fibrinolytic variables notably with a sex difference, which could be of importance for obesity-related CVD.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Leptin
ACE inhibitor
cardiovascular disease
PAI-1
fibrinolysis

Added entries (persons, corporate bodies, meetings, titles ...)

Söderberg, StefanUmeå universitet,Avdelningen för medicin(Swepub:umu)stso0001 (author)
Nilsson, Torbjörn K.Umeå universitet,Klinisk kemi(Swepub:umu)toni0049 (author)
Eriksson, Marie,ProfessorUmeå universitet,Statistik(Swepub:umu)maer0004 (author)
Boman, KurtUmeå universitet,Avdelningen för medicin(Swepub:umu)kubo0001 (author)
Jansson, Jan-HåkanUmeå universitet,Avdelningen för medicin(Swepub:umu)jaja0006 (author)
Umeå universitetAvdelningen för medicin (creator_code:org_t)

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In:Scandinavian Journal of Clinical and Laboratory Investigation: Taylor & Francis80:4, s. 303-3080036-55131502-7686

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