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Increased Serologic...
Increased Serological Response Against Human Herpesvirus 6A Is Associated With Risk for Multiple Sclerosis
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Engdahl, Elin (author)
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- Gustafsson, Rasmus (author)
- Karolinska Institutet
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Huang, Jesse (author)
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- Biström, Martin (author)
- Umeå universitet,Neurovetenskaper
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Lima Bomfim, Izaura (author)
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- Stridh, Pernilla (author)
- Karolinska Institutet
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- Khademi, Mohsen (author)
- Karolinska Institutet
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Brenner, Nicole (author)
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Butt, Julia (author)
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Michel, Angelika (author)
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- Jons, Daniel, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Hortlund, Maria (author)
- Karolinska Institutet
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Alonso-Magdalena, Lucia (author)
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- Hedström, Anna Karin (author)
- Karolinska Institutet
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Flamand, Louis (author)
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Ihira, Masaru (author)
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Yoshikawa, Tetsushi (author)
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- Andersen, Oluf, 1941 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Hillert, Jan (author)
- Karolinska Institutet
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- Alfredsson, Lars (author)
- Karolinska Institutet
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Waterboer, Tim (author)
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- Sundström, Peter (author)
- Umeå universitet,Neurovetenskaper
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- Olsson, Tomas (author)
- Karolinska Institutet
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- Kockum, Ingrid (author)
- Karolinska Institutet
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- Fogdell-Hahn, Anna (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-11-26
- 2019
- English.
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In: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 10
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- Human herpesvirus (HHV)-6A or HHV-6B involvement in multiple sclerosis (MS) etiology has remained controversial mainly due to the lack of serological methods that can distinguish the two viruses. A novel multiplex serological assay measuring IgG reactivity against the immediate-early protein 1 from HHV-6A (IE1A) and HHV-6B (IE1B) was used in a MS cohort (8,742 persons with MS and 7,215 matched controls), and a pre-MS cohort (478 individuals and 476 matched controls) to investigate this further. The IgG response against IE1A was positively associated with MS (OR = 1.55, p = 9 × 10-22), and increased risk of future MS (OR = 2.22, p = 2 × 10-5). An interaction was observed between IE1A and Epstein-Barr virus (EBV) antibody responses for MS risk (attributable proportion = 0.24, p = 6 × 10-6). In contrast, the IgG response against IE1B was negatively associated with MS (OR = 0.74, p = 6 × 10-11). The association did not differ between MS subtypes or vary with severity of disease. The genetic control of HHV-6A/B antibody responses were located to the Human Leukocyte Antigen (HLA) region and the strongest association for IE1A was the DRB1*13:01-DQA1*01:03-DQB1*06:03 haplotype while the main association for IE1B was DRB1*13:02-DQA1*01:02-DQB1*06:04. In conclusion a role for HHV-6A in MS etiology is supported by an increased serological response against HHV-6A IE1 protein, an interaction with EBV, and an association to HLA genes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Epstein-Barr virus
- association
- human herpesvirus 6A
- human herpesvirus 6B
- human leukocyte antigen
- multiple sclerosis
- risk
- serology
- human herpesvirus 6A
- human herpesvirus 6B
- multiple sclerosis
- association
- risk
- Epstein-Barr virus
- human leukocyte antigen
- serology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Engdahl, Elin
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Gustafsson, Rasm ...
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Huang, Jesse
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Biström, Martin
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Lima Bomfim, Iza ...
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Stridh, Pernilla
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show more...
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Khademi, Mohsen
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Brenner, Nicole
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Butt, Julia
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Michel, Angelika
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Jons, Daniel, 19 ...
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Hortlund, Maria
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Alonso-Magdalena ...
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Hedström, Anna K ...
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Flamand, Louis
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Ihira, Masaru
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Yoshikawa, Tetsu ...
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Andersen, Oluf, ...
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Hillert, Jan
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Alfredsson, Lars
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Waterboer, Tim
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Sundström, Peter
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Olsson, Tomas
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Kockum, Ingrid
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Fogdell-Hahn, An ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Frontiers in Imm ...
- By the university
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Umeå University
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Karolinska Institutet
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University of Gothenburg