Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity

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Fältnamn	Indikatorer	Metadata
000		03955naa a2200481 4500
001		oai:DiVA.org:umu-169440
003		SwePub
008		200406s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1694402 URI
024	7	a https://doi.org/10.1007/s11306-020-01653-72 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Bos, Maxime M.4 aut
245	1 0	a Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity
264		c 2020-03-02
264	1	b Springer,c 2020
338		a electronic2 rdacarrier
520		a Introduction: Several plasma metabolites have been associated with insulin resistance and type 2 diabetes mellitus.Objectives: We aimed to identify plasma metabolites associated with different indices of early disturbances in glucose metabolism and insulin sensitivity.Methods: This cross-sectional study was conducted in a subsample of the Leiden Longevity Study comprising individuals without a history of diabetes mellitus (n = 233) with a mean age of 63.3 ± 6.7 years of which 48.1% were men. We tested for associations of fasting glucose, fasting insulin, HOMA-IR, Matsuda Index, Insulinogenic Index and glycated hemoglobin with metabolites (Swedish Metabolomics Platform) using linear regression analysis adjusted for age, sex and BMI. Results were validated internally using an independent metabolomics platform (Biocrates platform) and replicated externally in the independent Netherlands Epidemiology of Obesity (NEO) study (Metabolon platform) (n = 545, mean age of 55.8 ± 6.0 years of which 48.6% were men). Moreover, in the NEO study, we replicated our analyses in individuals with diabetes mellitus (cases: n = 36; controls = 561).Results: Out of the 34 metabolites, a total of 12 plasma metabolites were associated with different indices of disturbances in glucose metabolism and insulin sensitivity in individuals without diabetes mellitus. These findings were validated using a different metabolomics platform as well as in an independent cohort of non-diabetics. Moreover, tyrosine, alanine, valine, tryptophan and alpha-ketoglutaric acid levels were higher in individuals with diabetes mellitus.Conclusion: We found several plasma metabolites that are associated with early disturbances in glucose metabolism and insulin sensitivity of which five were also higher in individuals with diabetes mellitus.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653		a Metabolomics
653		a Type 2 diabetes mellitus
653		a Glucose metabolism
653		a Insulin sensitivity
700	1	a Noordam, Raymond4 aut
700	1	a Bennett, Kate4 aut
700	1	a Beekman, Marian4 aut
700	1	a Mook-Kanamori, Dennis O.4 aut
700	1	a van Dijk, Ko4 aut
700	1	a Slagboom, P. Eline4 aut
700	1	a Lundstedt, Torbjorn4 aut
700	1	a Surowiec, Izabellau Umeå universitet,Kemiska institutionen,AcureOmics AB, Umeå, Sweden4 aut0 (Swepub:umu)izsu0001
700	1	a van Heemst, Diana4 aut
710	2	a Umeå universitetb Kemiska institutionen4 org
773	0	t Metabolomicsd : Springerg 16:3q 16:3x 1573-3882x 1573-3890
856	4	u https://doi.org/10.1007/s11306-020-01653-7y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1421843/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://link.springer.com/content/pdf/10.1007/s11306-020-01653-7.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169440
856	4 8	u https://doi.org/10.1007/s11306-020-01653-7

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By the author/editor: Bos, Maxime M.; Noordam, Raymond; Bennett, Kate; Beekman, Marian; Mook-Kanamori, D ...; van Dijk, Ko; show more...; Slagboom, P. Eli ...; Lundstedt, Torbj ...; Surowiec, Izabel ...; van Heemst, Dian ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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