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Bronchoalveolar mat...
Bronchoalveolar matrix metalloproteinase 9 relates to restrictive lung function impairment in systemic sclerosis.
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- Andersen, Grethe Neumann (author)
- Umeå universitet,Reumatologi
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- Nilsson, Kenneth (author)
- Umeå universitet,Lungmedicin
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- Pourazar, Jamshid (author)
- Umeå universitet,Lungmedicin
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Hackett, Tillie-Louise (author)
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Kazzam, Elsadig (author)
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- Blomberg, Anders (author)
- Umeå universitet,Lungmedicin
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- Waldenström, Anders (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Kardiologi
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Warner, Jane (author)
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- Rantapää-Dahlqvist, Solbritt (author)
- Umeå universitet,Reumatologi
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- Mincheva-Nilsson, Lucia (author)
- Umeå universitet,Klinisk immunologi
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Sandström, Thomas (author)
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: Respiratory Medicine. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 101:10, s. 2199-2206
- Related links:
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http://www.ncbi.nlm....
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http://www.resmedjou...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Systemic sclerosis (SSc) is frequently associated with interstitial lung disease (ILD) often leading to lung fibrosis. In this study we investigated whether matrix metalloproteinase 9 (MMP-9) and its natural inhibitor; the tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), would be associated with remodelling in ILD in SSc. Levels of total MMP-9, pro-MMP-9 and TIMP-1 were measured in bronchoalveolar lavage (BAL) fluid from nine SSc patients with ILD, seven SSc patients without ILD and 16 age- and sex-matched healthy controls. Total MMP-9 and pro-MMP-9 levels were significantly elevated in SSc patients with ILD, compared to levels in SSc patients without ILD and healthy controls. In SSc patients with ILD calculated active MMP-9 levels were significantly higher than in SSc patients without ILD and tended to be higher than in healthy controls. TIMP-1 levels were elevated in both patient groups compared to healthy controls. Total-, pro- and active MMP-9 levels as well as pro-MMP-TIMP-1 and active MMP-9/TIMP-1 ratios were inversely associated with total lung capacity. The present study suggests that MMP-9 plays a pathophysiological role in the remodelling in ILD and lung fibrosis associated with SSc, and may represent a new therapeutic target in this condition.
Publication and Content Type
- ref (subject category)
- art (subject category)
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