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  • Ekblom, Kim,1970-Umeå universitet,Klinisk kemi (author)

Iron stores and HFE genotypes are not related to increased risk of ischemic stroke. : a prospective nested case-referent study

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007-09-18
  • S. Karger AG,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-16977
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-16977URI
  • https://doi.org/10.1159/000108429DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: High iron levels can increase the formation of noxious oxygen radicals, which are thought to contribute to cerebrovascular disease. The aim of this prospective study was to determine if iron status and HFE genotypes constitute risk factors for stroke. Methods: First-ever stroke cases (231 ischemic and 42 hemorrhagic) and matched double referents from the population-based Northern Sweden cohorts were studied in a nested case-referent setting. Results: For total iron binding capacity, an increased risk of ischemic stroke was seen in the highest quartile (OR 1.80; 95% CI 1.14-2.83; p for trend 0.012). The highest quartile of transferrin iron saturation showed a decreased risk of ischemic stroke in men (OR 0.44; 95% CI 0.22-0.87; p for trend 0.028), but not in women. There was an increased risk of hemorrhagic stroke in the second (OR 4.07; 95% CI 1.09-15.20) and third quartile (OR 4.22; 95% CI 1.08-16.42) of ferritin. Neither quartiles of plasma iron concentrations nor the HFE C282Y and H63D genotypes were associated with ischemic or hemorrhagic stroke. Conclusions: Iron stores were not positively related to increased risk of ischemic stroke. Furthermore, HFE genotypes did not influence the risk of ischemic or hemorrhagic stroke. Copyright (c) 2007 S. Karger AG, Basel.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Hultdin, JohanUmeå universitet,Klinisk kemi(Swepub:umu)johu0007 (author)
  • Stegmayr, BirgittaUmeå universitet,Medicin(Swepub:umu)bist0001 (author)
  • Johansson, IngegerdUmeå universitet,Kariologi(Swepub:umu)injo0003 (author)
  • Van Guelpen, BethanyUmeå universitet,Patologi(Swepub:umu)beyvan99 (author)
  • Hallmans, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
  • Weinehall, LarsUmeå universitet,Epidemiologi och folkhälsovetenskap(Swepub:umu)lawe0001 (author)
  • Johansson, LarsUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)lrsjon80 (author)
  • Wiklund, Per-GunnarUmeå universitet,Medicin(Swepub:umu)pewi0010 (author)
  • Marklund, Stefan LUmeå universitet,Klinisk kemi(Swepub:umu)stma0003 (author)
  • Umeå universitetKlinisk kemi (creator_code:org_t)

Related titles

  • In:Cerebrovascular Diseases: S. Karger AG24:5, s. 405-4111015-97701421-9786

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