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Longitudinal dynami...
Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine
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Wec, Anna Z. (author)
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Haslwanter, Denise (author)
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Abdiche, Yasmina N. (author)
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Shehata, Laila (author)
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Pedreno-Lopez, Nuria (author)
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Moyer, Crystal L. (author)
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Bornholdt, Zachary A. (author)
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Lilov, Asparouh (author)
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Nett, Juergen H. (author)
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Jangra, Rohit K. (author)
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Brown, Michael (author)
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Watkins, David I. (author)
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- Ahlm, Clas, 1956- (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Clas Ahlm
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- Forsell, Mattias N. E. (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Mattias Forsell
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Rey, Felix A. (author)
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Barba-Spaeth, Giovanna (author)
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Chandran, Kartik (author)
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Walker, Laura M. (author)
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(creator_code:org_t)
- 2020-03-09
- 2020
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - Washington : National Academy of Science. - 0027-8424 .- 1091-6490. ; 117:12, s. 6675-6685
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https://umu.diva-por... (primary) (Raw object)
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Abstract
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- A comprehensive understanding of the development and evolution of human B cell responses duced by pathogen exposure will facilitate the design of next-generation vaccines. Here, we utilized a gh-throughput single B cell cloning technology to longitudinally track the human B cell response to the llow fever virus 17D (YFV-17D) vaccine. The earlymemory B cell (MBC) response was mediated by both assical immunoglobulin M (IgM) (IgM(+)CD27(+)) and switched immunoglobulin (swIg(+)) MBC pulations; however, classical IgM MBCs waned rapidly, whereas swIg(+) and atypical IgM(+) and IgD(+) MBCs were stable over time. Affinity maturation continued for 6 to 9 mo following vaccination, providing evidence for the persistence of germinal center activity long after the period of active viral replication in peripheral blood. Finally, a substantial fraction of the neutralizing antibody response was mediated by public clones that recognize a fusion loop-proximal antigenic site within domain II of the viral envelope glycoprotein. Overall, our findings provide a framework for understanding the dynamics and complexity of human B cell responses elicited by infection and vaccination.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- antiviral vaccination
- antibody responses
- yellow fever virus
- monoclonal antibody
- B cell memory
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wec, Anna Z.
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Haslwanter, Deni ...
-
Abdiche, Yasmina ...
-
Shehata, Laila
-
Pedreno-Lopez, N ...
-
Moyer, Crystal L ...
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show more...
-
Bornholdt, Zacha ...
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Lilov, Asparouh
-
Nett, Juergen H.
-
Jangra, Rohit K.
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Brown, Michael
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Watkins, David I ...
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Ahlm, Clas, 1956 ...
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Forsell, Mattias ...
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Rey, Felix A.
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Barba-Spaeth, Gi ...
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Chandran, Kartik
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Walker, Laura M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Proceedings of t ...
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Umeå University