Search: onr:"swepub:oai:DiVA.org:umu-169844" >
Body composition me...
Body composition measured by computed tomography is associated with colorectal cancer survival, also in early-stage disease
-
- Shirdel, Mona (author)
- Umeå universitet,Patologi
-
- Anderson, Fredrick (author)
- Umeå universitet,Onkologi
-
- Myte, Robin (author)
- Umeå universitet,Onkologi
-
show more...
-
- Axelsson, Jan, 1966- (author)
- Umeå universitet,Radiofysik
-
- Rutegård, Martin, 1982- (author)
- Umeå universitet,Kirurgi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
-
- Blomqvist, Lennart (author)
- Karolinska Institutet,Umeå universitet,Diagnostisk radiologi
-
- Riklund, Katrine, MD, PhD, Professor, 1963- (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
-
- van Guelpen, Bethany (author)
- Umeå universitet,Onkologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
-
- Palmqvist, Richard (author)
- Umeå universitet,Patologi
-
- Gylling, Björn, 1978- (author)
- Umeå universitet,Patologi
-
show less...
-
(creator_code:org_t)
- Taylor & Francis, 2020
- 2020
- English.
-
In: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 59:7, s. 799-808
- Related links:
-
https://umu.diva-por... (primary) (Raw object)
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Background: Cachexia and sarcopenia are associated with poor survival after colorectal cancer (CRC) diagnosis. Computed tomography (CT) can be used to measure aspects of cachexia including sarcopenia, myosteatosis and the amount of subcutaneous and visceral adipose tissue. The aim of this study was to relate CT-based body composition variables with survival outcomes in CRC.Material and methods: In this population-based, retrospective cohort study, CT scans of 974 patients with pathological stages I-IV CRCs, collected at or very near diagnosis (years 2000-2016), were used to measure cross-sectional fat and muscle tissue areas. Body composition variables based on these measurements were assessed in relation to tumor stage and site and cancer-specific survival in stages I-III CRC (n = 728) using Cox proportional hazards models and Kaplan-Meier estimators.Results: Sarcopenia was associated with decreased cancer-specific survival, especially in patients with stages I-II tumors. The hazard ratio (HR) for the lowest versus highest tertile of skeletal muscle index (SMI) was 1.67; 95% confidence interval (CI), 1.08-2.58 for all stages, and HR 2.22; 95% CI 1.06-4.68, for stages I-II. Myosteatosis was also associated with decreased cancer-specific survival [(HR 2.03; 95% CI 1.20-3.34 for the lowest versus the highest tertile of skeletal muscle radiodensity (SMR)]. SMI and SMR were lower in patients with right-sided CRC, independent of age and sex. No adipose tissue measurement was significantly associated with cancer-specific survival.Conclusion: In concordance with previous studies, sarcopenia and myosteatosis were associated with decreased cancer-specific survival. The strong association between sarcopenia and poor cancer-specific survival in early-stage disease could have clinical implications for personalizing therapy decisions, including nutritional support.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Shirdel, Mona
-
Anderson, Fredri ...
-
Myte, Robin
-
Axelsson, Jan, 1 ...
-
Rutegård, Martin ...
-
Blomqvist, Lenna ...
-
show more...
-
Riklund, Katrine ...
-
van Guelpen, Bet ...
-
Palmqvist, Richa ...
-
Gylling, Björn, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Acta Oncologica
- By the university
-
Umeå University
-
Karolinska Institutet