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Significance of PI3...
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Tumkur Sitaram, Raviprakash,1974-Umeå universitet,Patologi
(author)
Significance of PI3K Signalling pathway in clear cell renal cell carcinoma in relation to VHL and HIF status
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2020-05-28
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BMJ Publishing Group Ltd,2021
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Numbers
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LIBRIS-ID:oai:DiVA.org:umu-170709
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170709URI
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https://doi.org/10.1136/jclinpath-2020-206693DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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Renal cell carcinoma (RCC) includes diverse tumor types characterized by various genetic abnormalities. The genetic changes, like mutations, deletions, and epigenetic alterations, play a crucial role in the modification of signaling networks, tumor pathogenesis, and prognosis. The most prevalent RCC type, clear cell RCC (ccRCC), is asymptomatic in the early stages and has a poorer prognosis compared with the papillary and the chromophobe typesRCCs. Generally, ccRCC is refractory to chemotherapy and radiation therapy. Loss of VHL gene and upregulation of hypoxia-inducible factors (HIF), the signature of most sporadic ccRCC, promote multiple growth factors. Hence, VHL/HIF and a variety of pathways, including PTEN/PI3K/AKT, are closely connected and contribute to the ontogeny of ccRCC. In the recent decade, multiple targeting agents have been developed based on blocking major signaling pathways directly or indirectly involved in ccRCC tumor progression, metastasis, angiogenesis, and survival. However, most of these drugs have limitations; either metastatic ccRCC develops resistance to these agents, or despite blocking receptors, tumor cells utilize alternate signaling pathways. This review compiles the state of knowledge about the PI3K/AKT signaling pathway confined to ccRCC and their cross-talks with VHL/HIF pathways.
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Landström, MaréneUmeå universitet,Patologi(Swepub:umu)mala0231
(author)
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Roos, GöranUmeå universitet,Patologi(Swepub:umu)goro0001
(author)
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Ljungberg, Börje,Professor,1949-Umeå universitet,Urologi och andrologi(Swepub:umu)bolj0001
(author)
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Umeå universitetPatologi
(creator_code:org_t)
Related titles
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In:Journal of Clinical Pathology: BMJ Publishing Group Ltd74:4, s. 216-2220021-97461472-4146
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