Search: onr:"swepub:oai:DiVA.org:umu-171446" >
Residual colonizati...
Residual colonization by vaccine serotypes in rural South Africa four years following initiation of pneumococcal conjugate vaccine immunization
-
Madhi, Shabir A. (author)
-
Nzenze, Susan A. (author)
-
Nunes, Marta C. (author)
-
show more...
-
Chinyanganya, Lilian (author)
-
Van Niekerk, Nadia (author)
-
- Kahn, Kathleen (author)
- Umeå universitet,Institutionen för epidemiologi och global hälsa
-
Twine, Rhine (author)
-
De Gouveia, Linda (author)
-
Von Gottberg, Anne (author)
-
Shiri, Tinevimbo (author)
-
show less...
-
(creator_code:org_t)
- 2020-04-10
- 2020
- English.
-
In: Expert Review of Vaccines. - : Taylor & Francis. - 1476-0584 .- 1744-8395. ; 19:4, s. 383-393
- Related links:
-
https://archive.lstm...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Background: We evaluated pneumococcal colonization in children and adults between the time of 7-valent pneumococcal conjugate vaccine (PCV) introduction in the immunization program in 2009 to two years after transitioning to PCV13 in 2011.Methods: Community-based carriage surveillance was undertaken between May-November 2013 (Period-3), with similar surveys in 2009 (Period-1) and 2011 (Period-2). Households with children below two years had a similar probability of being sampled in all surveys. Nasopharyngeal swabs were processed using standard methods and serotyped by Quellung.Results: In children>9-59 months old, overall pneumococcal colonization prevalence declined from 81.8% in Period-1 to 65.0% in Period-3 (p<0.001). Reductions of 70% (41.2% vs. 13.6%) in PCV7-serotypes colonization and 66% (15.3% vs. 4.4%) for the six additional PCV13-serotypes (PCV13-add6VT) were observed. There was, however, high residual colonization by PCV7-serotypes 19F (14.9% vs. 6.3%) and 23F (8.5% vs. 4.1%), despite reduction of 57% and 52%, respectively. Among individuals>12 years of age, there was 61% reduction in PCV7-serotype colonization (3.1% vs. 1.3%) and 75% decrease for PCV13-add6VT (2.1% vs. 0.6%) between Period-1 and Period-3.Conclusions: The residual prevalence of serotypes 19F and 23F, four years after introducing PCV in the South Africa, suggests ongoing community transmission and transient vaccine effects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Streptococcus pneumoniae
- colonization
- carriage
- pneumococcal conjugate vaccine
- serotypes
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Madhi, Shabir A.
-
Nzenze, Susan A.
-
Nunes, Marta C.
-
Chinyanganya, Li ...
-
Van Niekerk, Nad ...
-
Kahn, Kathleen
-
show more...
-
Twine, Rhine
-
De Gouveia, Lind ...
-
Von Gottberg, An ...
-
Shiri, Tinevimbo
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Infectious Medic ...
- Articles in the publication
-
Expert Review of ...
- By the university
-
Umeå University