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Residual colonizati...
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Madhi, Shabir A.
(author)
Residual colonization by vaccine serotypes in rural South Africa four years following initiation of pneumococcal conjugate vaccine immunization
- Article/chapterEnglish2020
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2020-04-10
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Taylor & Francis,2020
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LIBRIS-ID:oai:DiVA.org:umu-171446
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-171446URI
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https://doi.org/10.1080/14760584.2020.1750377DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: We evaluated pneumococcal colonization in children and adults between the time of 7-valent pneumococcal conjugate vaccine (PCV) introduction in the immunization program in 2009 to two years after transitioning to PCV13 in 2011.Methods: Community-based carriage surveillance was undertaken between May-November 2013 (Period-3), with similar surveys in 2009 (Period-1) and 2011 (Period-2). Households with children below two years had a similar probability of being sampled in all surveys. Nasopharyngeal swabs were processed using standard methods and serotyped by Quellung.Results: In children>9-59 months old, overall pneumococcal colonization prevalence declined from 81.8% in Period-1 to 65.0% in Period-3 (p<0.001). Reductions of 70% (41.2% vs. 13.6%) in PCV7-serotypes colonization and 66% (15.3% vs. 4.4%) for the six additional PCV13-serotypes (PCV13-add6VT) were observed. There was, however, high residual colonization by PCV7-serotypes 19F (14.9% vs. 6.3%) and 23F (8.5% vs. 4.1%), despite reduction of 57% and 52%, respectively. Among individuals>12 years of age, there was 61% reduction in PCV7-serotype colonization (3.1% vs. 1.3%) and 75% decrease for PCV13-add6VT (2.1% vs. 0.6%) between Period-1 and Period-3.Conclusions: The residual prevalence of serotypes 19F and 23F, four years after introducing PCV in the South Africa, suggests ongoing community transmission and transient vaccine effects.
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Nzenze, Susan A.
(author)
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Nunes, Marta C.
(author)
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Chinyanganya, Lilian
(author)
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Van Niekerk, Nadia
(author)
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Kahn, KathleenUmeå universitet,Institutionen för epidemiologi och global hälsa(Swepub:umu)kaka0045
(author)
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Twine, Rhine
(author)
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De Gouveia, Linda
(author)
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Von Gottberg, Anne
(author)
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Shiri, Tinevimbo
(author)
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Umeå universitetInstitutionen för epidemiologi och global hälsa
(creator_code:org_t)
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In:Expert Review of Vaccines: Taylor & Francis19:4, s. 383-3931476-05841744-8395
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Madhi, Shabir A.
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Nzenze, Susan A.
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Nunes, Marta C.
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Chinyanganya, Li ...
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Van Niekerk, Nad ...
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Kahn, Kathleen
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Twine, Rhine
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De Gouveia, Lind ...
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Shiri, Tinevimbo
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Umeå University