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Prognostic scoring ...
Prognostic scoring systems and comorbidities in chronic myelomonocytic leukaemia : a nationwide population-based study
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- Moreno Berggren, Daniel (author)
- Uppsala universitet,Hematologi
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- Kjellander, Matilda (author)
- Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital and PO Hematology, Karolinska University Hospital, Stockholm, Sweden
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- Backlund, Ellen (author)
- Uppsala universitet,Hematologi
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- Engvall, Marie (author)
- Uppsala universitet,Medicinsk genetik och genomik
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- Garelius, Hege (author)
- Section for Haematology and Coagulation, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Lorenz, Fryderyk (author)
- Umeå universitet,Onkologi,Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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- Nilsson, Lars (author)
- Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden
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- Rasmussen, Bengt, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Lehmann, Sören (author)
- Karolinska Institutet,Uppsala universitet,Hematologi
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- Hellström-Lindberg, Eva (author)
- Karolinska Institutet
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- Jädersten, Martin (author)
- Karolinska Institutet
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- Ungerstedt, Johanna (author)
- Karolinska Institutet
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- Ejerblad, Elisabeth (author)
- Uppsala universitet,Hematologi
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(creator_code:org_t)
- 2020-06-05
- 2021
- English.
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In: British Journal of Haematology. - : John Wiley & Sons. - 0007-1048 .- 1365-2141. ; 192:3, s. 474-483
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Abstract
Subject headings
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- Outcomes in chronic myelomonocytic leukaemia (CMML) are highly variable and may be affected by comorbidity. Therefore, prognostic models and comorbidity indices are important tools to estimate survival and to guide clinicians in individualising treatment. In this nationwide population-based study, we assess comorbidities and for the first time validate comorbidity indices in CMML. We also compare the prognostic power of: the revised International Prognostic Scoring System (IPSS-R), CMML-specific prognostic scoring system (CPSS), MD Anderson Prognostic Scoring System (MDAPS) and Mayo score. In this cohort of 337 patients with CMML, diagnosed between 2009 and 2015, the median overall survival was 21 center dot 3 months. Autoimmune conditions were present in 25% of the patients, with polymyalgia rheumatica and Hashimoto's thyroiditis being most common. Of the tested comorbidity indices: the Charlson Comorbidity Index (CCI), Haematopoietic cell transplantation-specific Comorbidity Index (HCT-CI) and Myelodysplastic Syndrome-Specific Comorbidity Index (MDS-CI), CCI had the highest C-index (0 center dot 62) and was the only comorbidity index independently associated with survival in multivariable analyses. When comparing the prognostic power of the scoring systems, the CPSS had the highest C-index (0 center dot 69). In conclusion, using 'real-world' data we found that the CCI and CPSS have the best prognostic power and that autoimmune conditions are overrepresented in CMML.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- chronic myelomonocytic leukaemia (CMML)
- prognostic scores
- comorbidity index
- population-based study
- CMML-specific prognostic scoring system (CPSS)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Moreno Berggren, ...
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Kjellander, Mati ...
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Backlund, Ellen
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Engvall, Marie
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Garelius, Hege
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Lorenz, Fryderyk
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Nilsson, Lars
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Rasmussen, Bengt ...
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Lehmann, Sören
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Hellström-Lindbe ...
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Jädersten, Marti ...
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Ungerstedt, Joha ...
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Ejerblad, Elisab ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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British Journal ...
- By the university
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Umeå University
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Örebro University
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Uppsala University
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Karolinska Institutet