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Immune related prot...
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Landin, DavidKarolinska Institutet
(author)
Immune related proteins and tumor infiltratingCD8+ lymphocytes in hypopharyngeal cancer in relation to human papillomavirus (HPV) and clinical outcome
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-07
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John Wiley & Sons,2020
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-173590
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173590URI
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https://doi.org/10.1002/hed.26364DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:144109492URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Hypopharyngeal cancer (HPSCC) shows a poor clinical outcome, while HPSCC, caused by human papillomavirus (HPV), presents a better outcome. Here, HPCC, immune proteins, and tumor infiltrating CD8+ lymphocytes (CD8+ TILs) were evaluated in relation to HPV and outcome.Methods: Fresh frozen tissue from four HPV-positive HPSCC, 39 HPV-negative HPSCC, and normal samples were analyzed for protein expression by the Proseek immuno-oncology immunoassay. CD8+ TIL numbers evaluated by immunohistochemistry on 144 formalin-fixed biopsies were analyzed in relation to clinical outcome.Results: Proteins differing between HPV-positive and negative HPSCC included CD8A, PD-L1, Fas ligand, and chemokines. High CD8+ TIL numbers were correlated to improve clinical outcome in HPV-negative HPSCC.Conclusions: High expression of immune proteins in HPV-positive HPSCC may explain the better clinical outcome. CD8+ TILs are of relevance for outcome of HPV-negative HPSCC, while tumors with high immune activity but poor patient survival suggest a role for immune therapy.
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Ahrlund-Richter, Andreas
(author)
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Mirzaie, Leila
(author)
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Mints, MichaelUmeå universitet,Urologi och andrologi,Departement of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel(Swepub:umu)mimi0028
(author)
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Nasman, AndersKarolinska Institutet
(author)
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Kolev, AeneasKarolinska Institutet
(author)
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Marklund, LindaKarolinska Institutet
(author)
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Dalianis, TinaKarolinska Institutet
(author)
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Munck-Wikland, EvaKarolinska Institutet
(author)
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Ramqvist, TorbjornKarolinska Institutet
(author)
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Karolinska InstitutetUrologi och andrologi
(creator_code:org_t)
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In:Head and Neck: John Wiley & Sons42:11, s. 3206-32171043-30741097-0347
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Landin, David
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Ahrlund-Richter, ...
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Mirzaie, Leila
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Mints, Michael
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Nasman, Anders
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Kolev, Aeneas
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Marklund, Linda
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Dalianis, Tina
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Munck-Wikland, E ...
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Ramqvist, Torbjo ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Head and Neck
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Umeå University
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Karolinska Institutet