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  • Landin, DavidKarolinska Institutet (author)

Immune related proteins and tumor infiltratingCD8+ lymphocytes in hypopharyngeal cancer in relation to human papillomavirus (HPV) and clinical outcome

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-07
  • John Wiley & Sons,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-173590
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173590URI
  • https://doi.org/10.1002/hed.26364DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:144109492URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Hypopharyngeal cancer (HPSCC) shows a poor clinical outcome, while HPSCC, caused by human papillomavirus (HPV), presents a better outcome. Here, HPCC, immune proteins, and tumor infiltrating CD8+ lymphocytes (CD8+ TILs) were evaluated in relation to HPV and outcome.Methods: Fresh frozen tissue from four HPV-positive HPSCC, 39 HPV-negative HPSCC, and normal samples were analyzed for protein expression by the Proseek immuno-oncology immunoassay. CD8+ TIL numbers evaluated by immunohistochemistry on 144 formalin-fixed biopsies were analyzed in relation to clinical outcome.Results: Proteins differing between HPV-positive and negative HPSCC included CD8A, PD-L1, Fas ligand, and chemokines. High CD8+ TIL numbers were correlated to improve clinical outcome in HPV-negative HPSCC.Conclusions: High expression of immune proteins in HPV-positive HPSCC may explain the better clinical outcome. CD8+ TILs are of relevance for outcome of HPV-negative HPSCC, while tumors with high immune activity but poor patient survival suggest a role for immune therapy.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Ahrlund-Richter, Andreas (author)
  • Mirzaie, Leila (author)
  • Mints, MichaelUmeå universitet,Urologi och andrologi,Departement of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel(Swepub:umu)mimi0028 (author)
  • Nasman, AndersKarolinska Institutet (author)
  • Kolev, AeneasKarolinska Institutet (author)
  • Marklund, LindaKarolinska Institutet (author)
  • Dalianis, TinaKarolinska Institutet (author)
  • Munck-Wikland, EvaKarolinska Institutet (author)
  • Ramqvist, TorbjornKarolinska Institutet (author)
  • Karolinska InstitutetUrologi och andrologi (creator_code:org_t)

Related titles

  • In:Head and Neck: John Wiley & Sons42:11, s. 3206-32171043-30741097-0347

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