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Peptidoglycan editi...
Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare
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Le, Nguyen-Hung (author)
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Peters, Katharina (author)
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- Espaillat, Akbar, master, 1988- (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)
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Sheldon, Jessica R. (author)
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Gray, Joe (author)
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Di Venanzio, Gisela (author)
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Lopez, Juvenal (author)
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Djahanschiri, Bardya (author)
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Mueller, Elizabeth A. (author)
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Hennon, Seth W. (author)
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Levin, Petra Anne (author)
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Ebersberger, Ingo (author)
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Skaar, Eric P. (author)
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- Cava, Felipe (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Centre for Microbial Research (UCMR)
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Vollmer, Waldemar (author)
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Feldman, Mario F. (author)
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(creator_code:org_t)
- American Association for the Advancement of Science, 2020
- 2020
- English.
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In: Science Advances. - : American Association for the Advancement of Science. - 2375-2548. ; 6:30
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https://umu.diva-por... (primary) (Raw object)
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Abstract
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- Peptidoglycan (PG) is essential in most bacteria. Thus, it is often targeted by various assaults, including interbacterial attacks via the type VI secretion system (T6SS). Here, we report that the Gram-negative bacterium Acinetobacter baumannii strain ATCC 17978 produces, secretes, and incorporates the noncanonical D-amino acid D-lysine into its PG during stationary phase. We show that PG editing increases the competitiveness of A. baumannii during bacterial warfare by providing immunity against peptidoglycan-targeting T6SS effectors from various bacterial competitors. In contrast, we found that D-Lys production is detrimental to pathogenesis due, at least in part, to the activity of the human enzyme d-amino acid oxidase (DAO), which degrades D-Lys producing H2O2 toxic to bacteria. Phylogenetic analyses indicate that the last common ancestor of A. baumannii had the ability to produce D-Lys. However, this trait was independently lost multiple times, likely reflecting the evolution of A. baumannii as a human pathogen.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Le, Nguyen-Hung
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Peters, Katharin ...
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Espaillat, Akbar ...
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Sheldon, Jessica ...
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Gray, Joe
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Di Venanzio, Gis ...
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show more...
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Lopez, Juvenal
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Djahanschiri, Ba ...
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Mueller, Elizabe ...
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Hennon, Seth W.
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Levin, Petra Ann ...
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Ebersberger, Ing ...
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Skaar, Eric P.
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Cava, Felipe
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Vollmer, Waldema ...
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Feldman, Mario F ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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Umeå University