Search: onr:"swepub:oai:DiVA.org:umu-174533" >
Enhanement of amylo...
-
Adolfsson, Dan E.,1989-Umeå universitet,Kemiska institutionen,Fredrik Almqvist
(author)
Enhanement of amyloid fibril binding by ring expansion of thiazolino fused 2-pyridone peptidomimetics
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:DiVA.org:umu-174533
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174533URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:vet swepub-contenttype
-
Subject category:ovr swepub-publicationtype
Notes
-
Thiazolino fused 2-pyridones undergo thiazoline ring opening by reaction with 2-nitrobenzyl bromide through thi- oether attack, and base promoted fragmentation of the resulting sulfonium ions. Subsequent deprotonation of the benzylic carbon and intramolecular 1,4-addition leads to ring closure, generating dihydrothiazine fused 2-pyridones by net ring expansion of the thiazoline ring. Application of the ring expansion procedure to the pyridine and pyrimidine fused thiazolino 2-pyridones provided compounds with enhanced fibril binding activity.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Tyagi, MohitFredrik Almqvist
(author)
-
Singh, PardeepUmeå universitet,Kemiska institutionen,Fredrik Almqvist(Swepub:umu)pasi0012
(author)
-
Kaur, Amandeep
(author)
-
Ådén, Jörgen,1980-Umeå universitet,Kemiska institutionen(Swepub:umu)jonadn02
(author)
-
Bharate, Jaideep B.Fredrik Almqvist
(author)
-
Almqvist, FredrikUmeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR),Molekylär Infektionsmedicin, Sverige (MIMS)(Swepub:umu)fral0001
(author)
-
Umeå universitetKemiska institutionen
(creator_code:org_t)
Internet link
To the university's database