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  • Adolfsson, Dan E.,1989-Umeå universitet,Kemiska institutionen,Fredrik Almqvist (author)

Enhanement of amyloid fibril binding by ring expansion of thiazolino fused 2-pyridone peptidomimetics

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  • LIBRIS-ID:oai:DiVA.org:umu-174533
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174533URI

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  • Language:English
  • Summary in:English

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  • Subject category:vet swepub-contenttype
  • Subject category:ovr swepub-publicationtype

Notes

  • Thiazolino fused 2-pyridones undergo thiazoline ring opening by reaction with 2-nitrobenzyl bromide through thi- oether attack, and base promoted fragmentation of the resulting sulfonium ions. Subsequent deprotonation of the benzylic carbon and intramolecular 1,4-addition leads to ring closure, generating dihydrothiazine fused 2-pyridones by net ring expansion of the thiazoline ring. Application of the ring expansion procedure to the pyridine and pyrimidine fused thiazolino 2-pyridones provided compounds with enhanced fibril binding activity.

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  • Tyagi, MohitFredrik Almqvist (author)
  • Singh, PardeepUmeå universitet,Kemiska institutionen,Fredrik Almqvist(Swepub:umu)pasi0012 (author)
  • Kaur, Amandeep (author)
  • Ådén, Jörgen,1980-Umeå universitet,Kemiska institutionen(Swepub:umu)jonadn02 (author)
  • Bharate, Jaideep B.Fredrik Almqvist (author)
  • Almqvist, FredrikUmeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR),Molekylär Infektionsmedicin, Sverige (MIMS)(Swepub:umu)fral0001 (author)
  • Umeå universitetKemiska institutionen (creator_code:org_t)

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