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K2S2O8-mediated aer...
K2S2O8-mediated aerobic oxidative coupling of 6-amino-7-(aminomethyl)-thiazolino-pyridones with aldehydes : Direct access to highly functionalized pyrimidine fused thiazolino-2-pyridones with amyloid fibril binding activity or inhibitors of Amyloid-β fibril formation
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- Bharate, Jaideep B. (author)
- Fredrik Almqvist
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- Ådén, Jörgen, 1980- (author)
- Umeå universitet,Kemiska institutionen
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- Gharibyan, Anna (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Adolfsson, Dan E., 1989- (author)
- Umeå universitet,Kemiska institutionen,Fredrik Almqvist
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- Jayaweera, Sanduni Wasana (author)
- Anders Olofsson
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- Vielfort, Katarina (author)
- Umeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten),Molekylär Infektionsmedicin, Sverige (MIMS),Sven Bergström
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- Singh, Pardeep (author)
- Umeå universitet,Kemiska institutionen
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Tyagi, Mohit (author)
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- Bergström, Sven (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Olofsson, Anders, 1970- (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Almqvist, Fredrik (author)
- Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR),Molekylär Infektionsmedicin, Sverige (MIMS)
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(creator_code:org_t)
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- We herein present the synthesis of diversely functionalized pyrimidine fused thiazolino-2-pyridones via K2S2O8-mediated oxidative coupling of 6-amino-7-(aminomethyl)- thiazolino-2-pyridones with aldehydes. The developed protocol is mild, has wide substrate scope, and does not require transition metal catalyst or base. Some of the synthesized compounds have the ability to inhibit the formation of Amyloid-β fibrils associated with Alzheimer's disease, while others bind to mature Amyloid-β and α-Synuclein fibrils.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Publication and Content Type
- vet (subject category)
- ovr (subject category)
To the university's database
- By the author/editor
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Bharate, Jaideep ...
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Ådén, Jörgen, 19 ...
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Gharibyan, Anna
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Adolfsson, Dan E ...
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Jayaweera, Sandu ...
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Vielfort, Katari ...
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show more...
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Singh, Pardeep
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Tyagi, Mohit
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Bergström, Sven
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Olofsson, Anders ...
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Almqvist, Fredri ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Organic Chemistr ...
- By the university
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Umeå University