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Lung function and p...
Lung function and pulmonary vascular resistance are not associated in 6-year-old children born extremely preterm
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- Mohlkert, Lilly-Ann (author)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital
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- Sjöberg, Gunnar (author)
- Karolinska Institutet,Karolinska Institute
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- Rydberg, Annika (author)
- Umeå University,Umeå universitet,Pediatrik
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- Pegelow Halvorsen, Cecilia (author)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital
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- Tufvesson, Ellen (author)
- Lund University,Lunds universitet,Lungfysiologi och biomarkörer,Forskargrupper vid Lunds universitet,Lung physiology and biomarkers,Lund University Research Groups
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- Hallberg, Jenny (author)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital
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- Domellöf, Magnus, 1963- (author)
- Umeå University,Umeå universitet,Pediatrik
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- Norman, Mikael (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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(creator_code:org_t)
- 2019-10-10
- 2020
- English.
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In: Acta Paediatrica. - : John Wiley & Sons. - 0803-5253 .- 1651-2227. ; 109:4, s. 746-753
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Abstract
Subject headings
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- Aim: Children born preterm are at increased risk of reduced lung function. The aim was to test whether lung function was associated with pulmonary vascular resistance.Methods: Participants were recruited from a population-based cohort born in 2004-2007. Lung function was assessed with spirometry after administration of a beta2-agonist. Forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were determined. Estimations of pulmonary vascular resistance, arterial dimensions, right ventricular wall thickness, sphericity, and systolic (TAPSE) and diastolic functions were performed with echocardiography. Adjusted regression analyses were used to study associations.Results: Sixty-six children (33 boys) born at 22-26 weeks of gestational age (birthweights 460-1134 g) were assessed at a mean age of 6.7 years. Despite large variations in lung function with FVCz-scores ranging from -4.6 to +2.8, there were no associations between lung function and pulmonary arterial pressure, right ventricular structure or function. Children with higher FVCz-scores (r = .52, beta = .55 mm,P = .015) and higher FEV(1)z-scores (r = .58, beta = .73 mm,P = .001) exhibited larger pulmonary arteries.Conclusion: In children born extremely preterm, lung function was not associated with pulmonary vascular resistance. Routine echocardiographic evaluation of extremely preterm children may not be indicated at age 6.5 years.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- echocardiography
- extremely preterm
- lung function
- pulmonary circulation
- right heart function
- echocardiography
- extremely preterm
- lung function
- pulmonary circulation
- right heart function
Publication and Content Type
- ref (subject category)
- art (subject category)
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